Identifying and treating preclinical and early osteoarthritis.
Identifying and treating preclinical and early osteoarthritis.
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DOI：
10.1016/j.rdc.2014.07.012
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发表时间：
2014-11
影响因子：
2.3
通讯作者：
Hodgson, Richard
中科院分区：
文献类型：
--
作者：
Felson, David T.;Hodgson, Richard
骨关节炎是最常见的关节炎形式，非手术治疗的效果有限。研究表明，至少对于膝关节疾病来说，大多数患有疼痛性骨关节炎的人已经患有广泛的结构性疾病，包括排列不齐，这可能会阻碍疾病的成功稳定或逆转。这为制定预防疾病或及早发现和治疗疾病的策略提供了强有力的理由。本文综述的各种方法可能会捕获那些处于疾病高风险或患有早期疾病的人；成像技术有望在结构变化不可逆转之前对其进行表征。然而，由于缺乏有效的治疗方法，尚不清楚是否可以成功减缓或预防那些早期症状或疾病高危人群的结构性疾病。
Osteoarthritis is the most common form of arthritis and nonsurgical treatments of disease have limited efficacy. Studies suggest, at least for disease in the knee, that most persons with painful OA already have extensive structural disease including malalignment, which may preclude successful stabilization or reversal of disease. This provides a strong rationale for developing strategies to prevent disease or to identify and treat it early. A variety of approaches, reviewed here, are likely to capture those at high risk of or with early disease; imaging techniques offer great promise of characterizing structural changes before they are irreversible. However, given the absence of effective treatments, it is unclear whether structural disease could be successfully slowed or prevented in those with early symptoms or those at high risk of disease.
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影响因子：
7
作者：
Segal, N. A.;Glass, N. A.;Torner, J.;Yang, M.;Felson, D. T.;Sharma, L.;Nevitt, M.;Lewis, C. E.
通讯作者：
Lewis, C. E.
影响因子：
27.4
作者：
Sharma L;Chmiel JS;Almagor O;Felson D;Guermazi A;Roemer F;Lewis CE;Segal N;Torner J;Cooke TD;Hietpas J;Lynch J;Nevitt M
通讯作者：
Nevitt M
影响因子：
4.2
作者：
Valderrabano, Victor;Horisberger, Monika;Hintermann, Beat
通讯作者：
Hintermann, Beat
影响因子：
4.7
作者：
Oei, Edwin H. G.;van Tiel, Jasper;Robinson, William H.;Gold, Garry E.
通讯作者：
Gold, Garry E.
影响因子：
--
作者：
Lawrence, Reva C.;Felson, David T.;Wolfe, Frederick
通讯作者：
Wolfe, Frederick