Quantitative radiologic imaging techniques for articular cartilage composition: toward early diagnosis and development of disease-modifying therapeutics for osteoarthritis.
Quantitative radiologic imaging techniques for articular cartilage composition: toward early diagnosis and development of disease-modifying therapeutics for osteoarthritis.
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DOI：
10.1002/acr.22316
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发表时间：
2014-08
影响因子：
4.7
通讯作者：
Gold, Garry E.
中科院分区：
文献类型：
--
作者：
Oei, Edwin H. G.;van Tiel, Jasper;Robinson, William H.;Gold, Garry E.
骨关节炎（OA）是影响关节软骨和其他关节组织的最常见退行性关节疾病，导致严重的发病率和巨大的社会经济影响（1-3）。在美国，2005年有2700万人经历了OA（4）。2003年，美国关节炎和其他风湿性疾病的总成本为1280亿美元（5，6）。由于人口老龄化和肥胖率的增加，OA在未来几十年将变得更加普遍，预计到2030年将有6700万美国人被诊断患有关节炎（7）。OA的最终治疗选择是关节置换术，这与并发症有关，耐久性有限，并导致OA的高成本。因此，目前OA研究的重点是可能改善疾病的策略，如改善疾病的骨关节炎药物，软骨细胞植入，干细胞治疗或胫骨高位截骨术（8-10）。注意力还集中在可能预防或延迟OA发作的措施上，包括生活方式干预。这些策略都是在最有效的早期阶段针对OA，从而避免或延迟关节置换。
Osteoarthritis (OA) is the most common degenerative joint disease affecting articular cartilage and other joint tissues, resulting in serious morbidity and large socioeconomic impact (1–3). In the US, 27 million people experienced OA in 2005 (4). The total cost attributed to arthritis and other rheumatic conditions in the US was 128 billion dollars in 2003 (5, 6). Due to an aging population and increasing obesity rates, OA will become even more prevalent in the next decades with an estimated 67 million Americans expected to be diagnosed with arthritis by 2030 (7). The final treatment option for OA is joint replacement, which is associated with complications, limited durability, and contributes to the high costs of OA.Consequently, current OA research focuses on strategies that may be disease modifying, such as disease-modifying osteoarthritis drugs, chondrocyte implantation, stem cell therapy, or high tibial osteotomy (8–10). Attention is also focused on measures that may prevent or delay OA onset, including lifestyle interventions. These strategies all target OA at an early stage when they are most effective, thereby avoiding or delaying joint replacement.
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影响因子：
4.7
作者：
Baum, Thomas;Joseph, Gabby B.;Arulanandan, Ahilan;Nardo, Lorenzo;Virayavanich, Warapat;Carballido-Gamio, Julio;Nevitt, Michael C.;Lynch, John;McCulloch, Charles E.;Link, Thomas M.
通讯作者：
Link, Thomas M.
影响因子：
2.3
作者：
Bedson, John;Croft, Peter R.
通讯作者：
Croft, Peter R.
影响因子：
3.3
作者：
Bittersohl, Bernd;Hosalkar, Harish S.;Mamisch, Tallal C.
通讯作者：
Mamisch, Tallal C.
影响因子：
5.9
作者：
Chang, Gregory;Madelin, Guillaume;Regatte, Ravinder R.
通讯作者：
Regatte, Ravinder R.
影响因子：
3.3
作者：
Buck, Robert J.;Wyman, Bradley T.;Eckstein, Felix
通讯作者：
Eckstein, Felix