Endoscopic high-intensity focused US: technical aspects and studies in an in vivo porcine model (with video).
Endoscopic high-intensity focused US: technical aspects and studies in an in vivo porcine model (with video).
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DOI：
10.1016/j.gie.2014.12.019
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发表时间：
2015-05
影响因子：
7.7
通讯作者：
Hwang, Joo Ha
中科院分区：
文献类型：
--
作者：
Li, Tong;Khokhlova, Tatiana;Maloney, Ezekiel;Wang, Yak-Nam;D'Andrea, Samantha;Starr, Frank;Farr, Navid;Morrison, Kyle;Keilman, George;Hwang, Joo Ha
高强度聚焦超声（HIFU）正越来越广泛地用于良性和恶性肿瘤的无创和微创消融。最近的研究表明，高强度聚焦超声还可以增强靶向药物输送，并刺激许多肿瘤的抗肿瘤免疫反应。然而，由于缺乏足够的声窗，使用体外源靶向胰腺和肝脏肿瘤具有挑战性。内镜超声（EUS）引导的HIFU换能器的开发具有许多潜在的益处，包括改进靶向、降低能量需求和降低对介入结构的损伤的可能性。设计、开发和测试用于内窥镜应用的EUS引导HIFU换能器。临床前、中试表征和可行性研究。学术研究中心。在体内猪模型中进行研究。利用EUS引导聚焦超声经胃肠道对在体猪胰腺和肝脏进行热消融。换能器成功地在凝胶体模和离体牛肝脏中产生损伤。体内研究表明，在猪胰腺和肝脏中靶向和产生病变是可行的。这是一项临床前、单中心可行性研究，受试者数量有限。成功设计并开发了一种EUS引导的HIFU换能器，其尺寸适合内窥镜使用。已经在体内猪模型中证明了在体内进行EUS引导的HIFU消融的可行性。该技术的进一步发展将使内窥镜医师能够对腔周病变进行精确的治疗消融，而不会破坏胃肠道壁。
High-intensity focused ultrasound (HIFU) is becoming more widely used for non-invasive and minimally invasive ablation of benign and malignant tumors. Recent studies suggest that HIFU can also enhance targeted drug delivery and stimulate an anti-tumor immune response in many tumors. However, targeting of pancreatic and liver tumors using an extracorporeal source is challenging due to the lack of an adequate acoustic window. The development of an endoscopic ultrasound (EUS)-guided HIFU transducer has many potential benefits including improved targeting, decreased energy requirements and decreased potential for injury to intervening structures. To design, develop and test an EUS-guided HIFU transducer for endoscopic applications. A pre-clinical, pilot characterization and feasibility study. Academic research center. Studies were performed in an in vivo porcine model. Thermal ablation of in vivo porcine pancreas and liver was performed with EUS guided focused ultrasound through the gastric tract. The transducer successfully created lesions in gel phantoms and ex vivo bovine livers. In vivo studies demonstrated that targeting and creating lesions in the porcine pancreas and liver are feasible. This is a pre-clinical, single-center feasibility study with a limited number of subjects. An EUS-guided HIFU transducer was successfully designed and developed with dimensions that are appropriate for endoscopic use. Feasibility of performing EUS-guided HIFU ablation in vivo has been demonstrated in an in vivo porcine model. Further development of this technology will allow endoscopists to perform precise therapeutic ablation of peri-lumenal lesions without breaching the wall of the gastric tract.
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影响因子：
2.9
作者：
Wang, Yak-Nam;Khokhlova, Tatiana;Bailey, Michael;Hwang, Joo Ha;Khokhlova, Vera
通讯作者：
Khokhlova, Vera
影响因子：
2.4
作者：
Khokhlova, Tatiana D.;Canney, Michael S.;Bailey, Michael R.
通讯作者：
Bailey, Michael R.
影响因子：
--
作者：
Jung, Seung Eun;Cho, Se Hyun;Han, Joon-Yeol
通讯作者：
Han, Joon-Yeol
影响因子：
2.9
作者：
Lafon, C;Zderic, V;Vaezy, S
通讯作者：
Vaezy, S
影响因子：
2.4
作者：
Khokhlova, VA;Bailey, MR;Crum, LA
通讯作者：
Crum, LA