The antibiotic resistance "mobilome": searching for the link between environment and clinic.
The antibiotic resistance "mobilome": searching for the link between environment and clinic.
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DOI：
10.3389/fmicb.2013.00138
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发表时间：
2013
影响因子：
5.2
通讯作者：
Wright GD
中科院分区：
文献类型：
--
作者：
Perry JA;Wright GD
抗生素耐药性是一个古老的问题，这是由于数千年来土壤和其他环境中的产毒生物和目标生物的共同进化。环境“耐药基因组”是所有直接或间接导致抗生素耐药性的基因的集合。这些耐药决定簇中的许多源自产寄生虫的生物体（在那里它们用于介导自身免疫），而其他耐药决定簇只有在非天然宿主中动员和过度表达时才成为耐药决定簇（如质粒编码的β-内酰胺酶）。现代环境抗性组受到人类活动（如农业）的选择压力，这可能会影响局部抗性组的组成并导致基因转移事件。除了环境之外，我们在临床上也面临着抗生素耐药病原体频率和多样性增加的挑战。我们假设临床耐药起源于环境，但环境耐药基因组和临床耐药基因组之间直接基因交换的例子很少。有强有力的证据表明，临床氨基糖苷类和万古霉素耐药酶、超广谱β-内酰胺酶CTX-M和喹诺酮类耐药基因qnr与环境耐药基因组有直接联系。在这篇综述中，我们强调了最近的进展，我们的理解水平基因转移的抗生素耐药基因从环境中的临床。测序技术的改进加上功能宏基因组研究揭示了以前未被充分认识的环境抗性组的多样性，并建立了新的遗传联系的临床。了解基因交换的机制对于控制抗生素耐药性的未来传播至关重要。
Antibiotic resistance is an ancient problem, owing to the co-evolution of antibiotic-producing and target organisms in the soil and other environments over millennia. The environmental “resistome” is the collection of all genes that directly or indirectly contribute to antibiotic resistance. Many of these resistance determinants originate in antibiotic-producing organisms (where they serve to mediate self-immunity), while others become resistance determinants only when mobilized and over-expressed in non-native hosts (like plasmid-encoded β-lactamases). The modern environmental resistome is under selective pressure from human activities such as agriculture, which may influence the composition of the local resistome and lead to gene transfer events. Beyond the environment, we are challenged in the clinic by the rise in both frequency and diversity of antibiotic resistant pathogens. We assume that clinical resistance originated in the environment, but few examples of direct gene exchange between the environmental resistome and the clinical resistome have been documented. Strong evidence exists to suggest that clinical aminoglycoside and vancomycin resistance enzymes, the extended-spectrum β-lactamase CTX-M and the quinolone resistance gene qnr have direct links to the environmental resistome. In this review, we highlight recent advances in our understanding of horizontal gene transfer of antibiotic resistance genes from the environment to the clinic. Improvements in sequencing technologies coupled with functional metagenomic studies have revealed previously underappreciated diversity in the environmental resistome, and also established novel genetic links to the clinic. Understanding mechanisms of gene exchange becomes vital in controlling the future dissemination of antibiotic resistance.
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揭示了整合静脉细菌中结合元素的普遍性和多样性。
影响因子：
3.7
作者：
Ghinet MG;Bordeleau E;Beaudin J;Brzezinski R;Roy S;Burrus V
通讯作者：
Burrus V
影响因子：
4.9
作者：
Colomer-Lluch, Marta;Imamovic, Lejla;Muniesa, Maite
通讯作者：
Muniesa, Maite
影响因子：
64.8
作者：
HUGHES, VM;DATTA, N
通讯作者：
DATTA, N
DOI：
10.1126/science.1220761
发表时间：
2012-08-31
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Forsberg KJ;Reyes A;Wang B;Selleck EM;Sommer MO;Dantas G
通讯作者：
Dantas G
影响因子：
6.4
作者：
Allen HK;Looft T;Bayles DO;Humphrey S;Levine UY;Alt D;Stanton TB
通讯作者：
Stanton TB