Fecal-oral transmission of SARS-CoV-2: review of laboratory-confirmed virus in gastrointestinal system.
Fecal-oral transmission of SARS-CoV-2: review of laboratory-confirmed virus in gastrointestinal system.
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DOI：
10.1007/s00384-020-03785-7
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发表时间：
2021-03
影响因子：
2.8
通讯作者：
Poggioli G
中科院分区：
文献类型：
--
作者：
Cuicchi D;Lazzarotto T;Poggioli G
目的是收集关于实验室确认的严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）在胃肠道系统中存在的可用数据，并评估消化系统是否有助于病毒传播。检索了文献数据库，以确定所有记录了确诊为2019年冠状病毒病（COVID-19）的成年患者中：（1）粪便中存在SARS-CoV-2核糖核酸;（2）肠道细胞中存在SARS-CoV-2核糖核酸;（3）粪便中存在SARS-CoV-2活病毒的研究。27例符合入选标准。在26项研究中，报告了COVID-19患者粪便中是否存在SARS-CoV-2核糖核酸。在671例患者中，312例（46.5%）粪便样本病毒核酸阳性。在这些患者中，63.9%的患者在咽拭子变为阴性后粪便中病毒核酸仍为阳性; 3项研究还评估了胃肠道组织中的病毒核糖核酸，在检查的8例患者中有3例（37.5%）样本中发现了SARS-CoV-2核酸。在两项研究中证实了粪便样本中存在活病毒，但在德国最近的一项研究中没有。提示SARS-CoV-2可感染胃肠道上皮细胞，并可能通过消化道传播。为了控制这一流行病，应尽一切努力了解感染的所有可能传播途径，即使是不太重要的途径。
The objective was to collect the data available regarding the presence of laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in gastrointestinal system and to evaluate whether the digestive system could contribute to viral transmission. Bibliographic databases were searched to identify all studies documenting, in adult patients with a confirmed diagnosis of coronavirus disease 2019 (COVID-19): (1) the presence of SARS-CoV-2 ribonucleic acid in the feces; (2) the presence of SARS-CoV-2 ribonucleic acid in the intestinal cells; (3) live SARS-CoV-2 in the feces. Twenty seven met the inclusion criteria. In 26 studies, the presence or absence of SARS-CoV-2 ribonucleic acid in the feces of COVID-19 patients had been reported. Out of the 671 patients, 312 (46.5%) had a positive stool sample for viral nucleic acid. Of these patients, 63.9% remained positive for viral nucleic acid in the feces after pharyngeal swabs became negative; Three studies also evaluated the viral ribonucleic acid in the gastrointestinal tissues and the presence of SARS-CoV-2 nucleic acid was found in samples of 3 patients out of 8 examined (37.5%). The presence of the live virus in stool samples was confirmed in two studies but no in in a recent study from Germany. These results suggested that SARS-CoV-2 could infect gastrointestinal epithelial cells and it may be transmitted through the digestive tract. In order to control the pandemic, every effort should be made to understand all the possible routes of transmission of the infections, even the less important ones.
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