Dendritic cells that have interacted with antigen are targets for natural killer cells
Dendritic cells that have interacted with antigen are targets for natural killer cells
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与抗原相互作用的树突状细胞是自然杀伤细胞的目标
DOI：
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发表时间：
1985
影响因子：
15.3
通讯作者：
D. Rowley
中科院分区：
文献类型：
--
作者：
P. Shah;S. Gilbertson;D. Rowley
自然杀伤（NK）细胞（poly I：C诱导的、X射线抗性、非粘附性、Thy-1-、Ly-1.1-、Ly-2.1-、抗去唾液酸GM 1阳性和对YAC-1具有细胞毒性）抑制混合淋巴细胞反应（MLR）和自体MLR培养物中的T淋巴细胞增殖。树突状细胞（DC）的淋巴细胞增殖所需的两种反应。淋巴细胞或DC是否是NK细胞的靶标的问题通过利用NK细胞而不是DC在培养24小时后失去活性的事实来解决。三项发现表明，DC，而不是淋巴细胞，是NK细胞的靶点。首先，NK细胞抑制的反应完全恢复，加入少量的DC培养24小时后，NK细胞已被添加。第二，单独与NK细胞和抗原孵育24小时的DC不刺激淋巴细胞增殖。第三，单独与NK细胞孵育24 h的淋巴细胞在加入DC时增殖正常。另外的实验表明，DC仅在与抗原相互作用后才成为靶。因此，我们认为NK细胞可能通过监测DC的抗原呈递来调节淋巴细胞增殖。
Natural killer (NK) cells (poly I:C induced, x-ray resistant, nonadherent, Thy-1-, Ly-1.1-, Ly-2.1-, anti-asialo GM1-positive, and cytotoxic for YAC-1) suppressed T lymphocyte proliferation in mixed lymphocyte reaction (MLR) and autologous MLR cultures. Dendritic cells (DC) were required for proliferation of lymphocytes in both responses. The question whether lymphocytes or DC were the targets for NK cells was resolved by taking advantage of the fact that NK cells, but not DC, lose activity after 24 h in culture. Three findings indicate that DC, not lymphocytes, are targets for NK cells. First, responses suppressed by NK cells were fully restored by adding small numbers of DC to cultures 24 h after NK cells had been added. Second, DC incubated alone with NK cells and antigen for 24 h did not stimulate proliferation of lymphocytes. Third, lymphocytes incubated alone with NK cells for 24 h proliferated normally when DC were added. Additional experiments showed that DC became targets only after interaction with antigen. Thus, we suggest that NK cells may regulate lymphocyte proliferation by monitoring antigen presentation by DC.
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病毒感染期间的自然细胞介导的免疫。
影响因子：
--
作者：
Welsh,RM
通讯作者：
Welsh,RM
NK 细胞对小鼠抵抗病毒 (HSV-1) 感染的体内意义。
DOI：
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发表时间：
1984
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Habu,S;Akamatsu,K;Tamaoki,N;Okumura,K
通讯作者：
Okumura,K
DOI：
--
发表时间：
1983
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Wright,SC;Weitzen,ML;Kahle,R;Granger,GA;Bonavida,B
通讯作者：
Bonavida,B
DOI：
10.1073/pnas.80.19.6041
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
INABA, K;STEINMAN, RM;MURAMATSU, S
通讯作者：
MURAMATSU, S
自然杀伤细胞对同基因造血祖细胞发育的影响。
DOI：
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发表时间：
1984
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Holmberg,LA;Miller,BA;Ault,KA
通讯作者：
Ault,KA