Non-Invasive Brain Stimulation in Children With Unilateral Cerebral Palsy: A Protocol and Risk Mitigation Guide.
Non-Invasive Brain Stimulation in Children With Unilateral Cerebral Palsy: A Protocol and Risk Mitigation Guide.
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DOI：
10.3389/fped.2018.00056
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发表时间：
2018
影响因子：
2.6
通讯作者：
Friel K
中科院分区：
文献类型：
--
作者：
Gillick BT;Gordon AM;Feyma T;Krach LE;Carmel J;Rich TL;Bleyenheuft Y;Friel K
非侵入性脑刺激已被越来越多地研究，主要是在成人中，目的是影响中风后的运动恢复。然而，关于安全性和最佳研究设计的共识尚未在儿科建立。在有或无临床疾病的成人中，报告的主要不良事件发生率较低，这加快了NIBS在儿童中的探索，其平行目的是影响神经损伤后的运动技能发展。考虑到儿童的发育变异性，无论是否有神经系统诊断，成人剂量和方案可能不合适。本文的目的是提出预防和减轻单侧脑瘫（UCP）患儿NIBS期间不良事件（ae）的建议和工具。我们的建议为儿童NIBS研究设计提供了一个框架。本报告的主要内容包括：(a)相关文献摘要，提供背景证据；(b)预测和管理来自四个国际儿科实验室的ae的工具。这些建议为评估NIBS在UCP患儿中的安全性和风险缓解提供了初步指南。一致的安全性、可行性和耐受性报告将完善NIBS实践指南，有助于NIBS的未来临床翻译。
Non-invasive brain stimulation has been increasingly investigated, mainly in adults, with the aims of influencing motor recovery after stroke. However, a consensus on safety and optimal study design has not been established in pediatrics. The low incidence of reported major adverse events in adults with and without clinical conditions has expedited the exploration of NIBS in children with paralleled purposes to influence motor skill development after neurological injury. Considering developmental variability in children, with or without a neurologic diagnosis, adult dosing and protocols may not be appropriate. The purpose of this paper is to present recommendations and tools for the prevention and mitigation of adverse events (AEs) during NIBS in children with unilateral cerebral palsy (UCP). Our recommendations provide a framework for pediatric NIBS study design. The key components of this report on NIBS AEs are (a) a summary of related literature to provide the background evidence and (b) tools for anticipating and managing AEs from four international pediatric laboratories. These recommendations provide a preliminary guide for the assessment of safety and risk mitigation of NIBS in children with UCP. Consistent reporting of safety, feasibility, and tolerability will refine NIBS practice guidelines contributing to future clinical translations of NIBS.
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影响因子：
3.1
作者：
Bleyenheuft Y;Dricot L;Gilis N;Kuo HC;Grandin C;Bleyenheuft C;Gordon AM;Friel KM
通讯作者：
Friel KM
影响因子：
3.1
作者：
Collange Grecco, Luanda Andre;Carvalho Duarte, Natalia de Almeida;Oliveira, Claudia Santos
通讯作者：
Oliveira, Claudia Santos
影响因子：
4.2
作者：
Bleyenheuft, Yannick;Arnould, Carlyne;Gordon, Andrew M.
通讯作者：
Gordon, Andrew M.
影响因子：
14.5
作者：
BROUWER, B;ASHBY, P
通讯作者：
ASHBY, P
影响因子：
14.5
作者：
CARR, LJ;HARRISON, LM;STEPHENS, JA
通讯作者：
STEPHENS, JA