The brain-derived neurotrophic factor Val66Met polymorphism predicts response to exposure therapy in posttraumatic stress disorder.
The brain-derived neurotrophic factor Val66Met polymorphism predicts response to exposure therapy in posttraumatic stress disorder.
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DOI：
10.1016/j.biopsych.2012.10.033
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发表时间：
2013-06-01
影响因子：
10.6
通讯作者：
Bryant, Richard A.
中科院分区：
文献类型：
--
作者：
Felmingham, Kim L.;Dobson-Stone, Carol;Schofield, Peter R.;Quirk, Gregory J.;Bryant, Richard A.
创伤后应激障碍（PTSD）最有效的治疗方法是暴露疗法，其目的是促进条件性恐惧的消退。最近的证据表明，脑源性神经营养因子（BDNF）促进灭绝学习。这项研究评估了BDNF的Met-66等位基因是否会导致较低的活动依赖性分泌，预测PTSD对暴露治疗的反应不良。55例PTSD患者接受了为期8周的基于确认的认知行为治疗计划，并提供口腔拭子或唾液提取基因组DNA以确定其BDNF Val 66 Met基因型（30例患者具有瓦尔/瓦尔BDNF等位基因，25例患者具有Met-66等位基因）。我们研究了BDNF基因型是否能预测暴露治疗后PTSD严重程度的降低。分析显示，与携带瓦尔/瓦尔等位基因的患者相比，携带BDNF Met-66等位基因的PTSD患者对暴露疗法的反应较差。治疗前临床医生管理的PTSD量表严重程度和BDNF Val 66 Met多态性使用分层回归预测暴露治疗的反应。这项研究提供了第一个证据，BDNF Val 66 Met基因型预测PTSD认知行为治疗的反应，并与BDNF促进消退学习的证据雅阁。
The most effective treatment for posttraumatic stress disorder (PTSD) is exposure therapy, which aims to facilitate extinction of conditioned fear. Recent evidence suggests that brain-derived neurotrophic factor (BDNF) facilitates extinction learning. This study assessed whether the Met-66 allele of BDNF, which results in lower activity-dependent secretion, predicts poor response to exposure therapy in PTSD. Fifty-five patients with PTSD underwent an 8-week exposure-based cognitive behavior therapy program and provided mouth swabs or saliva to extract genomic DNA to determine their BDNF Val66Met genotype (30 patients with the Val/Val BDNF allele, 25 patients with the Met-66 allele). We examined whether BDNF genotype predicted reduction in PTSD severity following exposure therapy. Analyses revealed poorer response to exposure therapy in the PTSD patients with the Met-66 allele of BDNF compared with patients with the Val/Val allele. Pretreatment Clinician Administered PTSD Scale severity and BDNF Val66Met polymorphism predicted response to exposure therapy using hierarchical regression. This study provides the first evidence that the BDNF Val66Met genotype predicts response to cognitive behavior therapy in PTSD and is in accord with evidence that BDNF facilitates extinction learning.
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DOI：
10.1523/jneurosci.2021-06.2006
发表时间：
2006-09-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kalisch R;Korenfeld E;Stephan KE;Weiskopf N;Seymour B;Dolan RJ
通讯作者：
Dolan RJ
DOI：
10.1196/annals.1301.012
发表时间：
2003-01-01
期刊：
ROOTS OF MENTAL ILLNESS IN CHILDREN
影响因子：
--
作者：
Rothbaum, BO;Davis, M
通讯作者：
Davis, M
影响因子：
15.9
作者：
Mahan, Amy L.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
DOI：
10.1073/pnas.0909359107
发表时间：
2010-02-09
影响因子：
11.1
作者：
Choi, Dennis C.;Maguschak, Kimberly A.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
影响因子：
10.6
作者：
Bryant, Richard A.;Felmingham, Kim L.;Schofield, Peter R.
通讯作者：
Schofield, Peter R.