Redox theory of aging.
Redox theory of aging.
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DOI：
10.1016/j.redox.2015.03.004
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发表时间：
2015-08
期刊：
影响因子：
11.4
通讯作者：
Jones, Dean P.
中科院分区：
文献类型：
--
作者：
Jones, Dean P.
后生动物基因组编码暴露记忆系统，以提高生存和生殖潜力，提供机制，为个人调整在生命周期中的环境资源和挑战。这些系统本质上是氧化还原网络，在复杂系统的进化过程中产生，O2是生物能量学，代谢和结构组织，防御和繁殖的主要决定因素。网络结构从概念开始就降低了灵活性，这是由于对环境的分化和累积反应（麻烦）。衰老的氧化还原理论认为，衰老是由于分化和暴露记忆系统的执行而发生的基因组-染色体组相互作用的可塑性下降。这包括线粒体和生物能量灵活性受损，食物利用和代谢稳态受损，屏障和防御能力下降以及生殖保真度和繁殖力丧失。这一理论解释了衰老的特征，包括未能维持氧化或异生素防御、线粒体完整性、蛋白质稳态、屏障结构、DNA修复、端粒、免疫功能、代谢调节和再生能力。氧化还原界面连接生物体及其环境。遗传编码暴露记忆系统进化沿着与多细胞在氧气丰富的环境。暴露记忆允许个体在生命周期中适应资源和威胁。老化是由于暴露记忆系统的执行而导致的适应性的不可逆转的下降。
Metazoan genomes encode exposure memory systems to enhance survival and reproductive potential by providing mechanisms for an individual to adjust during lifespan to environmental resources and challenges. These systems are inherently redox networks, arising during evolution of complex systems with O2 as a major determinant of bioenergetics, metabolic and structural organization, defense, and reproduction. The network structure decreases flexibility from conception onward due to differentiation and cumulative responses to environment (exposome). The redox theory of aging is that aging is a decline in plasticity of genome–exposome interaction that occurs as a consequence of execution of differentiation and exposure memory systems. This includes compromised mitochondrial and bioenergetic flexibility, impaired food utilization and metabolic homeostasis, decreased barrier and defense capabilities and loss of reproductive fidelity and fecundity. This theory accounts for hallmarks of aging, including failure to maintain oxidative or xenobiotic defenses, mitochondrial integrity, proteostasis, barrier structures, DNA repair, telomeres, immune function, metabolic regulation and regenerative capacity. A redox interface connects an organism and its environment. Genetically encoded exposure memory systems evolved along with multicellularity in an O2-rich environment. Exposure memory allows an individual to adapt to resources and threats during lifespan. Aging is an irreversible decline in adaptability due to execution of exposure memory systems.
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影响因子：
64.5
作者：
López-Otín C;Blasco MA;Partridge L;Serrano M;Kroemer G
通讯作者：
Kroemer G
影响因子：
7
作者：
Go, Young-Mi;Roede, James R.;Jones, Dean P.
通讯作者：
Jones, Dean P.
影响因子：
9.9
作者：
通讯作者：
--
影响因子：
11.4
作者：
Go YM;Jones DP
通讯作者：
Jones DP
影响因子：
64.8
作者：
Ivanov, PC;Amaral, LAN;Stanley, HE
通讯作者：
Stanley, HE