Human papillomavirus, smoking, and head and neck cancer.

Human papillomavirus, smoking, and head and neck cancer.
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DOI:
10.1016/j.amjoto.2011.02.001
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发表时间:
2012-01
影响因子:
2.5
通讯作者:
Mendenhall, William M.
Mendenhall, William M.
中科院分区:
医学3区
文献类型:
--
作者:
Sinha, Parul;Logan, Henrietta L.;Mendenhall, William M.

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吸烟和人乳头瘤病毒(HPV)是头颈部癌的两个不同的危险因素,但这两个危险因素在头颈部癌发生中的相互作用的性质尚不清楚。本文综述了吸烟在HPV相关头颈部癌发病中的潜在作用。使用关键词人乳头瘤病毒、头颈癌、吸烟、烟草和宫颈癌进行文献检索。收集和分析英文文献、参考文献和其他相关研究,评价吸烟、HPV和头颈癌风险之间的关系。总体而言,我们的审查指出,吸烟对HPV感染存在的头颈癌的发展构成额外的风险。这与现有的实验室数据一致,这些数据显示了吸烟与HPV感染进展至致癌之间相互作用的生物学可接受性证据。因此,促进HPV感染的吸烟者戒烟非常重要。
Smoking and human papillomavirus (HPV) are both distinct risk factors for head and neck cancer but the nature of interaction between these two risk factors in development of head and neck cancer remains unclear The purpose of this review is to determine the potential effect of smoking in causation of HPV related head and neck carcinoma. A literature search was carried out using keywords human papillomavirus, head and neck cancer, smoking, tobacco, and cervical cancer. The English language articles, references and other relevant studies evaluating the association of smoking, HPV and risk of head and neck cancer were collected and analyzed. Overall, our review points to smoking tobacco posing an additional risk for development of head and neck cancer in the presence of HPV infection. This is consistent with available laboratory data which show evidence of biological plausibility for interaction between smoking and progression of HPV infection to carcinogenesis. It is therefore important that cessation of smoking is promoted in smokers with HPV infection.
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发表时间: 2008-04-01
期刊: CARCINOGENESIS
影响因子: 4.7
作者:
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