Sirh7/Ldoc1 knockout mice exhibit placental P4 overproduction and delayed parturition.
Sirh7/Ldoc1 knockout mice exhibit placental P4 overproduction and delayed parturition.
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DOI：
10.1242/dev.114520
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Kaneko-Ishino T
中科院分区：
文献类型：
--
作者：
Naruse M;Ono R;Irie M;Nakamura K;Furuse T;Hino T;Oda K;Kashimura M;Yamada I;Wakana S;Yokoyama M;Ishino F;Kaneko-Ishino T
Sirh 7/Ldoc 1 [sushi-ichi retrotransposon homolog 7/leucine zipper，downregulated in cancer 1，也称为mammalian retrotransposon-derived 7（Mart 7）]是真兽目哺乳动物中新获得的来自LTR逆转录转座子的基因之一。有趣的是，Sirh 7/Ldoc 1敲除（KO）小鼠表现出异常的胎盘细胞分化/成熟，导致胎盘孕酮（P4）和胎盘催乳素1（PL 1）从滋养层巨细胞（TGC）过度生产。胎盘是哺乳动物胎生所必需的器官，在妊娠期间除了为胎儿提供营养和氧气外，还起着重要的内分泌作用。P4是哺乳动物准备和维持妊娠以及确定分娩时间的必需激素;然而，啮齿动物胎盘P4的生物学意义尚未得到正确认识。在这里，我们证明了小鼠胎盘在妊娠中期产生P4，与卵巢P4的时间减少相一致，这表明它在保护孕体中起作用，特别是在这一时期。怀孕的Sirh 7/LDoc 1基因敲除雌性还表现出与幼崽断奶率低相关的分娩延迟。所有这些结果表明，Sirh 7/Ldoc 1作为真兽目特有的获得性基因在真兽目进化过程中经历了正选择，因为它通过调节胎盘内分泌功能影响生殖适合度。
Sirh7/Ldoc1 [sushi-ichi retrotransposon homolog 7/leucine zipper, downregulated in cancer 1, also called mammalian retrotransposon-derived 7 (Mart7)] is one of the newly acquired genes from LTR retrotransposons in eutherian mammals. Interestingly, Sirh7/Ldoc1 knockout (KO) mice exhibited abnormal placental cell differentiation/maturation, leading to an overproduction of placental progesterone (P4) and placental lactogen 1 (PL1) from trophoblast giant cells (TGCs). The placenta is an organ that is essential for mammalian viviparity and plays a major endocrinological role during pregnancy in addition to providing nutrients and oxygen to the fetus. P4 is an essential hormone in the preparation and maintenance of pregnancy and the determination of the timing of parturition in mammals; however, the biological significance of placental P4 in rodents is not properly recognized. Here, we demonstrate that mouse placentas do produce P4 in mid-gestation, coincident with a temporal reduction in ovarian P4, suggesting that it plays a role in the protection of the conceptuses specifically in this period. Pregnant Sirh7/Ldoc1 knockout females also displayed delayed parturition associated with a low pup weaning rate. All these results suggest that Sirh7/Ldoc1 has undergone positive selection during eutherian evolution as a eutherian-specific acquired gene because it impacts reproductive fitness via the regulation of placental endocrine function.
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影响因子：
4.4
作者：
Simmons, David G.;Rawn, Saara;Davies, Alastair;Hughes, Martha;Cross, James C.
通讯作者：
Cross, James C.
影响因子：
5.2
作者：
Kaneko-Ishino T;Ishino F
通讯作者：
Ishino F
影响因子：
--
作者：
Piekorz, RP;Gingras, B;Weinstein, Y
通讯作者：
Weinstein, Y
DOI：
10.1002/jez.b.21239
发表时间：
2009-09-15
影响因子：
2.2
作者：
Freyer, Claudia;Renfree, Marilyn B.
通讯作者：
Renfree, Marilyn B.
影响因子：
4.8
作者：
Arensburg, J;Payne, AH;Orly, J
通讯作者：
Orly, J