Maternal Stress Potentiates the Effect of an Inflammatory Diet in Pregnancy on Maternal Concentrations of Tumor Necrosis Factor Alpha.
Maternal Stress Potentiates the Effect of an Inflammatory Diet in Pregnancy on Maternal Concentrations of Tumor Necrosis Factor Alpha.
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DOI：
10.3390/nu10091252
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发表时间：
2018-09-06
期刊：
影响因子：
5.9
通讯作者：
Entringer S
中科院分区：
文献类型：
--
作者：
Lindsay KL;Buss C;Wadhwa PD;Entringer S
怀孕期间的母体炎症已知会对胎儿发育、出生结局和后代的身心健康产生不利影响。饮食和压力已被确定为炎症的重要决定因素，但它们的综合影响尚未在怀孕的情况下进行研究。本研究旨在探讨孕妇饮食与炎症电位和心理应激之间的关系，并确定它们对妊娠期间肿瘤坏死因子(TNF)-α浓度的相互作用。我们对n = 202名妇女进行了一项前瞻性纵向研究，在怀孕期间进行了三种评估，包括：使用感知压力量表（PSS）短版的母体压力生态瞬时评估（EMA）；24小时饮食回顾，从中计算饮食炎症指数（DII）；血清中TNF-α的测定。在整个怀孕期间，更高的感知压力与更促炎的饮食有关（r = 0.137; p < 0.05）。在校正协变量的线性回归模型中，DII与TNF-α呈正相关（B = 0.093, p = 0.010）。在报告应激水平较高的女性中，促炎饮食对TNF-α浓度的影响更为明显（B = 0.134, p = 0.018）。这些结果强调了在怀孕期间炎症的背景下同时考虑营养和压力的必要性。
Maternal inflammation during pregnancy is known to adversely impact fetal development, birth outcomes, and offspring physical and mental health. Diet and stress have been identified as important determinants of inflammation, yet their combined effects have not been examined in the context of pregnancy. The aim of this study was to examine the relationship between maternal diet with inflammatory potential and psychological stress, and to determine their interaction effect on concentrations of tumor necrosis factor (TNF)-α across pregnancy. We conducted a prospective longitudinal study of n = 202 women with three assessments during pregnancy, which included: ecological momentary assessment (EMA) of maternal stress using the perceived stress scale (PSS) short version; 24-h dietary recalls from which the dietary inflammatory index (DII) was computed; and serum measurements of TNF-α. Across pregnancy, higher perceived stress was associated with consumption of a more pro-inflammatory diet (r = 0.137; p < 0.05). In a linear regression model adjusted for covariates, DII was positively associated with TNF-α (B = 0.093, p = 0.010). The effect of the pro-inflammatory diet on concentrations of TNF-α was more pronounced in women reporting higher levels of stress (B = 0.134, p = 0.018 for DII*PSS interaction). These results highlight the need to consider nutrition and stress concurrently in the context of inflammation during pregnancy.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
3.8
作者：
Christian, Lisa M.;Porter, Kyle
通讯作者：
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影响因子：
5.9
作者：
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通讯作者：
Pruimboom L
DOI：
10.1016/j.jand.2014.03.015
发表时间：
2014-11-01
影响因子：
4.8
作者：
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通讯作者：
White, Emily
影响因子：
6
作者：
Carpentier, Pamela A.;Dingman, Andra L.;Palmer, Theo D.
通讯作者：
Palmer, Theo D.