Response preparation and inhibition: the role of the cortical sensorimotor beta rhythm.
Response preparation and inhibition: the role of the cortical sensorimotor beta rhythm.
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DOI：
10.1016/j.neuroscience.2008.06.061
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发表时间：
2008-09-22
期刊：
影响因子：
3.3
通讯作者：
Ding, M.
中科院分区：
文献类型：
--
作者：
Zhang, Y.;Chen, Y.;Bressler, S. L.;Ding, M.
需要GO或NO-GO反应的范式通常用于研究反应抑制的神经机制。在这里，这个问题是从事件相关的β（14-30赫兹）振荡活动的角度进行审查。两个猕猴执行一项任务，开始与自我启动的杠杆下压和维护（持续的电机输出），并需要一个视觉模式的歧视，然后要么杠杆释放（GO）或持续握杆（NO-GO）的反应。分析同时局部场电位（LFPs）从初级躯体感觉，额叶运动，后顶叶皮层，我们报告两个结果。首先，β振荡在刺激呈现后不久去极化，其开始对于GO和NO-GO条件两者大致相同（约110 ms）。由于众所周知，β去兴奋是运动准备的可靠指标，因此该结果表明，在两种情况下都发生了早期运动准备。第二，在GO/NO-GO决定之后（约190 ms），β活性仅在NO-GO条件下显著反弹（约300 ms）。连贯性和格兰杰因果关系的措施表明，反弹的β网络的动态组织是类似的，存在于持续的运动输出刺激开始之前。这一发现表明，反应抑制导致感觉运动网络恢复到刺激前状态。
Paradigms requiring either a GO or a NO-GO response are often used to study the neural mechanisms of response inhibition. Here this issue is examined from the perspective of event-related beta (14-30 Hz) oscillatory activity. Two macaque monkeys performed a task that began with a self-initiated lever depression and maintenance (sustained motor output) and required a visual pattern discrimination followed by either a lever release (GO) or continued lever-holding (NO-GO) response. Analyzing simultaneous local field potentials (LFPs) from primary somatosensory, frontal motor, and posterior parietal cortices, we report two results. First, beta oscillation desynchronized shortly after stimulus presentation, the onset of which was approximately the same for both the GO and NO-GO conditions (∼110 ms). Since it is well known that beta desynchronization is a reliable indicator of movement preparation, this result suggests that early motor preparation took place in both conditions. Second, following the GO/NO-GO decision (∼190 ms), beta activity rebounded significantly (∼300 ms) only in the NO-GO condition. Coherence and Granger causality measures revealed that the dynamical organization of the rebounded beta network was similar to that existing during the sustained motor output prior to stimulus onset. This finding suggests that response inhibition led to the restoration of the sensorimotor network to its prestimulus state.
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DOI：
10.1073/pnas.0308538101
发表时间：
2004-06-29
影响因子：
11.1
作者：
Brovelli, A;Ding, MZ;Bressler, SL
通讯作者：
Bressler, SL
影响因子：
1.9
作者：
Ding, MZ;Bressler, SL;Liang, HL
通讯作者：
Liang, HL
影响因子：
1.7
作者：
Kiefer, M;Marzinzik, F;Spitzer, M
通讯作者：
Spitzer, M
影响因子：
2.6
作者：
EIMER, M
通讯作者：
EIMER, M
影响因子：
14.5
作者：
Konishi, S;Nakajima, K;Miyashita, Y
通讯作者：
Miyashita, Y