The effect of a silk Fibroin/Polyurethane blend patch on rat Vessels
The effect of a silk Fibroin/Polyurethane blend patch on rat Vessels
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丝素蛋白/聚氨酯混合贴剂对大鼠血管的影响
DOI：
10.1080/15476278.2017.1344376
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发表时间：
2017
期刊：
影响因子：
2.3
通讯作者：
Tanaka Ryou
中科院分区：
文献类型：
--
作者：
Shimada Kazumi;Higuchi Akira;Kubo Ryota;Murakami Tomoaki;Nakazawa Yasumoto;Tanaka Ryou
补片移植物广泛应用于各种血管手术中，如血管狭窄的检测、修复或扩张。膨体聚四氟乙烯(EPTFE)贴片很灵活，手感很好，但由于它们不能被生物吸收，因此会永久留在体内，因此出现了钙化问题。开发一种替代的生物兼容贴片是很重要的。丝素蛋白(SF)是一种生物相容性材料，但作为补片缺乏手术所需的弹性。聚氨酯(PU)也是一种著名的弹性体，因此本研究重点研究了SF及其重量比为5：5(SF/PU)的PU共混材料。为了评价SF/PU补片，将补片植入大鼠的腹主动脉，对照组使用ePTFE补片。因为SF/PU贴片比ePTFE贴片更灵活，所以更容易植入。植入后1周，SF/PU贴片已有大量细胞和胶原纤维渗入。EPTFE对照贴片直到3个月才积累胶原纤维，4周时出现钙化。SF/PU贴片在3个月内没有任何钙化迹象。这项研究解决了与单独使用SF相关的问题，并表明SF/PU贴片可以被认为是ePTFE的有效替代品，以克服钙化问题。
Patch grafts are widely used in various kind of vascular surgeries such as detect repair or dilation of vascular stenosis. Expanded polytetrafluoroethylene (ePTFE) patches are flexible and handle well, but have shown problems with calcification as they are non-bioabsorbable and therefore permanently remain in the body. It is important to develop an alternative biocompatible patch. Silk fibroin (SF) was developed as a biocompatible material, but it lacks of the elasticity required for surgery as a patch. Polyurethane (PU) is also a well-known elastomer so this study focused on the SF and the PU blend materials with a weight ratio of 5:5 (SF/PU). To evaluate the SF/PU patch, the patches were implanted into the abdominal aortas of rats, using the ePTFE patch in the control group. Because it was more flexible the SF/PU patch was easier to implant than the ePTFE patch. At 1 week after implantation, the SF/PU patch had been infiltrated with cells and collagen fiber. The ePTFE control patch did not accumulate collagen fiber until 3 months and calcification occurred at 4 weeks. The SF/PU patch did not present any signs of calcification for 3 months. This study addressed the problems associated with using SF in isolation and showed that the SF/PU patch can be considered as a useful alternative to the ePTFE to overcome the problem of calcification.
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用于开发基于丝素蛋白和聚氨酯的非织造生物材料的固态核磁共振研究
DOI：
--
发表时间：
2017
期刊：
影响因子：
--
作者：
Chikako T. Nakazawa;Akira Higuchi;A. Asano;T. Kameda;D. Aytemiz;Y. Nakazawa
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影响因子：
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作者：
W. J. Huang;F. Hu;S. Chang
通讯作者：
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影响因子：
4.3
作者：
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通讯作者：
Sata, Masataka
影响因子：
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作者：
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通讯作者：
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