Cholecalciferol attenuates perseverative behavior associated with developmental alcohol exposure in rats in a dose-dependent manner.
Cholecalciferol attenuates perseverative behavior associated with developmental alcohol exposure in rats in a dose-dependent manner.
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DOI：
10.1016/j.jsbmb.2012.10.012
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发表时间：
2013-07
影响因子：
4.1
通讯作者：
Thomas, J. D.
中科院分区：
文献类型：
--
作者：
Idrus, N. M.;Happer, J. P.;Thomas, J. D.
酒精是一种已知的致畸剂，估计会影响美国2-5%的新生儿。产前酒精暴露会产生身体特征，如面部畸形，生理改变，如中枢神经系统（CNS）中的细胞丢失，以及行为变化，包括多动症，认知缺陷和运动功能障碍。与产前酒精暴露相关的影响范围被称为胎儿酒精谱系障碍（FASD）。尽管采取了预防措施，但一些妇女在怀孕期间继续饮酒。因此，确定降低FASD严重程度的干预措施至关重要。这项研究调查了一种潜在的干预措施，维生素D3，一种具有神经保护作用的营养素。本研究确定胆钙化醇，一种常见的维生素D3营养补充剂，是否可以作为减轻酒精相关学习障碍的一种手段。使用FASD大鼠模型，在妊娠晚期暴露于酒精之前、期间和之后给予胆钙化醇。胆钙化醇治疗后三周，受试者进行了一系列空间辨别逆转学习任务的测试。与对照组相比，暴露于乙醇的动物犯了更多的错误。胆钙化醇治疗以剂量依赖性方式减少了与发育期酒精暴露相关的持续行为。这些数据对FASD的治疗具有重要意义，并表明胆钙化醇可以减少FASD的某些方面。
Alcohol is a known teratogen that is estimated to affect 2–5% of the births in the U.S. Prenatal alcohol exposure can produce physical features such as facial dysmorphology, physiological alterations such as cell loss in the central nervous system (CNS), and behavioral changes that include hyperactivity, cognitive deficits, and motor dysfunction. The range of effects associated with prenatal alcohol exposure is referred to as fetal alcohol spectrum disorders (FASD). Despite preventative measures, some women continue to drink while pregnant. Therefore, identifying interventions that reduce the severity of FASD is critical. This study investigated one such potential intervention, vitamin D3, a nutrient that exerts neuroprotective properties. The present study determined whether cholecalciferol, a common vitamin D3 nutritional supplement, could serve as a means of mitigating alcohol-related learning deficits. Using a rat model of FASD, cholecalciferol was given before, during, and after 3rd trimester equivalent alcohol exposure. Three weeks after cholecalciferol treatment, subjects were tested on a serial spatial discrimination reversal learning task. Animals exposed to ethanol committed significantly more errors compared to controls. Cholecalciferol treatment reduced perseverative behavior that is associated with developmental alcohol exposure in a dose-dependent manner. These data have important implications for the treatment of FASD and suggest that cholecalciferol may reduce some aspects of FASD.
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影响因子：
2.7
作者：
Bardgett, ME;Griffith, MS;O'Connell, SM
通讯作者：
O'Connell, SM
影响因子：
6.7
作者：
DOBBING, J;SMART, JL
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SMART, JL
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3.7
作者：
Eyles, D W;Feron, F;Burne, T H J
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3.3
作者：
Eyles, D;Brown, J;Feron, F
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Feron, F
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作者：
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Minisola, S.