Partial pressure of oxygen in adipose tissue and its relationship with fatness in a natural animal model of extreme fat deposition, the grey seal.
Partial pressure of oxygen in adipose tissue and its relationship with fatness in a natural animal model of extreme fat deposition, the grey seal.
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DOI：
10.14814/phy2.14972
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发表时间：
2021-08
影响因子：
2.5
通讯作者：
Rocha J
中科院分区：
文献类型：
--
作者：
Oller L;Bennett KA;McKnight JC;Moss SEW;Milne R;Hall AJ;Rocha J
过度肥胖与人体氧分压改变和合并症有关。相比之下，海洋哺乳动物具有高脂肪，没有明显的有害影响。然而，在他们的皮下脂肪组织（鲸脂）的氧分压（Po 2）及其与肥胖的关系还没有报道。我们测量了12个健康的青少年灰海豹在不同的鲸脂深度的PO 2和温度。肥满度估计从鲸脂厚度和形态参数。同时，我们监测呼吸模式;使用脉搏血氧仪监测心率和动脉血氧饱和度;使用近红外光谱（NIRS）作为局部氧合变化的代表，监测脂肪毛细血管中总血红蛋白、脱氧血红蛋白和氧合血红蛋白的相对变化。鲸脂Po 2范围为14.5至71.4 mmHg（39.2 ± 14.1 mmHg），与其他物种中报告的值相似。鲸脂Po 2与脂肪度呈强负相关（LME：p < 0.0001，R2边际= 0.53，R2条件= 0.64，n = 10），但与鲸脂深度无关。没有其他参数解释Po 2的变异性，表明动脉血和局部氧输送在测量内和测量之间没有变化。海豹脂肪含量的下降与脂肪含量的增加是一致的，与其他动物模型的快速脂肪沉积。然而，脂肪变得缺氧的Po 2水平以及低脂肪Po 2对其健康和功能的影响，特别是在非常肥胖的个体中，仍然未知。尽管海豹的肥胖率很高，而且波动很大，但它们如何避免脂肪组织中低氧张力的有害影响，这是一个值得探索的富有成效的途径。灰海豹鲸脂Po 2是类似于在其他哺乳动物物种和负相关的脂肪，独立的深度测量，氧气输送，或温度。
Excessive adiposity is associated with altered oxygen tension and comorbidities in humans. In contrast, marine mammals have high adiposity with no apparent detrimental effects. However, partial pressure of oxygen (Po2) in their subcutaneous adipose tissue (blubber) and its relationship with fatness have not been reported. We measured Po2 and temperature at different blubber depths in 12 healthy juvenile grey seals. Fatness was estimated from blubber thickness and morphometric parameters. Simultaneously, we monitored breathing pattern; heart rate and arterial blood saturation with a pulse oximeter; and relative changes in total hemoglobin, deoxyhemoglobin, and oxyhemoglobin in blubber capillaries using near‐infrared spectroscopy (NIRS) as proxies for local oxygenation changes. Blubber Po2 ranged from 14.5 to 71.4 mmHg (39.2 ± 14.1 mmHg), which is similar to values reported in other species. Blubber Po2 was strongly and negatively associated with fatness (LME: p < 0.0001, R 2 marginal = 0.53, R 2 conditional = 0.64, n = 10), but not with blubber depth. No other parameters explained variability in Po2, suggesting arterial blood and local oxygen delivery did not vary within and between measurements. The fall in blubber Po2 with increased fatness in seals is consistent with other animal models of rapid fat deposition. However, the Po2 levels at which blubber becomes hypoxic and consequences of low blubber Po2 for its health and function, particularly in very fat individuals, remain unknown. How seals avoid detrimental effects of low oxygen tension in adipose tissue, despite their high and fluctuating adiposity, is a fruitful avenue to explore. Grey seals blubber Po2 is similar to that measured in other mammal species and negatively associated with fatness, independently of depth of measurement, oxygen delivery, or temperature.
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影响因子：
2.9
作者：
Hiltebrand, Luzius B.;Kaiser, Heiko A.;Kurz, Andrea
通讯作者：
Kurz, Andrea
影响因子：
2.3
作者：
Arnold, Todd W.
通讯作者：
Arnold, Todd W.
影响因子：
8.8
作者：
Kabon, B;Nagele, A;Kurz, A
通讯作者：
Kurz, A
DOI：
10.1139/z88-007
发表时间：
1988-01-01
期刊：
CANADIAN JOURNAL OF ZOOLOGY-REVUE CANADIENNE DE ZOOLOGIE
影响因子：
--
作者：
FEDAK, MA;PULLEN, MR;KANWISHER, J
通讯作者：
KANWISHER, J
影响因子：
5.8
作者：
Goossens, Gijs H.;Vogel, Max A. A.;Blaak, Ellen E.
通讯作者：
Blaak, Ellen E.