Intrusion Errors and Progression of Cognitive Deficits in Older Adults with Mild Cognitive Impairment and PreMCI States.
Intrusion Errors and Progression of Cognitive Deficits in Older Adults with Mild Cognitive Impairment and PreMCI States.
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DOI：
10.1159/000512804
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发表时间：
2021
影响因子：
2.4
通讯作者：
Loewenstein DA
中科院分区：
文献类型：
--
作者：
Crocco EA;Curiel Cid R;Kitaigorodsky M;Grau GA;Garcia JM;Duara R;Barker W;Chirinos CL;Rodriguez R;Loewenstein DA
在患有遗忘型轻度认知障碍（aMCI）的人中，测量主动语义干扰的子量表上的侵入错误可能是阿尔茨海默病（AD）脑病理学升高的最早的行为标志物之一。虽然在该领域已经有相当多的横断面工作，但目前尚不清楚语义侵入错误是否能预测aMCI或PreMCI（认知不正常但不符合MCI的全部标准）中认知障碍的进展。本研究检查了基于新型认知应激测试LASSI-L的总反应的语义侵入错误（PIE）百分比在多大程度上可以预测最初诊断为aMCI，PreMCI和正常认知的老年人平均26个月的临床/认知结果。在对主动语义干扰敏感的LASSI-L子量表上，PIE 44%侵入错误的临界点区分了那些随着时间推移进展为MCI的PreMCI高危个体与那些在纵向随访中恢复正常的PreMCI个体。重要的是，PIE能够准确预测83.3%的aMCI患者后来发展为痴呆症。这些初步研究结果表明，PIE的LASSI-L分量表，衡量积极的语义干扰可能是一个有用的预测临床进展的风险老年人。
Among persons with amnestic mild cognitive impairment (aMCI), intrusion errors on subscales that measure proactive semantic interference may be among the earliest behavioral markers of elevated Alzheimer’s disease (AD) brain pathology. While there has been considerable cross-sectional work in the area, it is presently unknown whether semantic intrusion errors are predictive of progression of cognitive impairment in aMCI or PreMCI (not cognitively normal but not meeting full criteria for MCI). This study examined the extent to which the percentage of semantic intrusion errors (PIE) based on total responses on a novel cognitive stress test, the LASSI-L, could predict clinical/cognitive outcomes over an average 26 month period in older adults initially diagnosed with aMCI, PreMCI and normal cognition. On the LASSI-L subscale sensitive to proactive semantic interference, a PIE cut-point of 44% intrusion errors distinguished between those at-risk individuals with PreMCI who progressed to MCI over time compared to individuals with PreMCI who reverted to normal on longitudinal follow-up. Importantly, PIE was able to accurately predict 83.3% of aMCI individuals who later progressed to dementia. These preliminary findings indicate that PIE on LASSI-L subscales that measure proactive semantic interference may be a useful predictor of clinical progression overtime in at-risk older adults.
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影响因子：
2.5
作者：
Rouleau, I;Imbault, H;Bédard, MA
通讯作者：
Bédard, MA
影响因子：
2.4
作者：
Thomas, Kelsey R.;Eppig, Joel;Bondi, Mark W.
通讯作者：
Bondi, Mark W.
用于检测社区老年人轻度认知障碍的简短计算机配对测试。
DOI：
10.3233/jad-160370
发表时间：
2016-09-06
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Curiel RE;Crocco E;Rosado M;Duara R;Greig MT;Raffo A;Loewenstein DA
通讯作者：
Loewenstein DA
影响因子：
4
作者：
Loewenstein, David A.;Curiel, Rosie E.;Duara, Ranjan
通讯作者：
Duara, Ranjan
影响因子：
2.4
作者：
Torres, Valeria L.;Rosselli, Monica;Duara, Ranjan
通讯作者：
Duara, Ranjan