Quantitative trait loci and transcriptome signatures associated with avian heritable resistance to Campylobacter.
Quantitative trait loci and transcriptome signatures associated with avian heritable resistance to Campylobacter.
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DOI：
10.1038/s41598-020-79005-7
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发表时间：
2021-01-12
影响因子：
4.6
通讯作者：
Stevens MP
中科院分区：
文献类型：
--
作者：
Psifidi A;Kranis A;Rothwell LM;Bremner A;Russell K;Robledo D;Bush SJ;Fife M;Hocking PM;Banos G;Hume DA;Kaufman J;Bailey RA;Avendano S;Watson KA;Kaiser P;Stevens MP
Campylobacter is the leading cause of bacterial foodborne gastroenteritis worldwide. Handling or consumption of contaminated poultry meat is a key risk factor for human campylobacteriosis. One potential control strategy is to select poultry with increased resistance to Campylobacter. We associated high-density genome-wide genotypes (600K single nucleotide polymorphisms) of 3000 commercial broilers with Campylobacter load in their caeca. Trait heritability was modest but significant (h2 = 0.11 ± 0.03). Results confirmed quantitative trait loci (QTL) on chromosomes 14 and 16 previously identified in inbred chicken lines, and detected two additional QTLs on chromosomes 19 and 26. RNA-Seq analysis of broilers at the extremes of colonisation phenotype identified differentially transcribed genes within the QTL on chromosome 16 and proximal to the major histocompatibility complex (MHC) locus. We identified strong cis-QTLs located within MHC suggesting the presence of cis-acting variation in MHC class I and II and BG genes. Pathway and network analyses implicated cooperative functional pathways and networks in colonisation, including those related to antigen presentation, innate and adaptive immune responses, calcium, and renin–angiotensin signalling. While co-selection for enhanced resistance and other breeding goals is feasible, the frequency of resistance-associated alleles was high in the population studied and non-genetic factors significantly influenced Campylobacter colonisation.
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影响因子：
4.4
作者：
Chaloner, Gemma;Wigley, Paul;Williams, Nicola
通讯作者：
Williams, Nicola
影响因子：
3.7
作者：
Bishop SC;Woolliams JA
通讯作者：
Woolliams JA
DOI：
10.1534/g3.113.006031
发表时间：
2013-05-20
期刊：
G3 (Bethesda, Md.)
影响因子：
--
作者：
Connell S;Meade KG;Allan B;Lloyd AT;Downing T;O'Farrelly C;Bradley DG
通讯作者：
Bradley DG
影响因子：
3.1
作者：
Calenge, Fanny;Vignal, Alain;Beaumont, Catherine
通讯作者：
Beaumont, Catherine
影响因子：
3.3
作者：
Andreoletti, Olivier;Budka, Herbert;Vanopdenbosch, Emmanuel
通讯作者：
Vanopdenbosch, Emmanuel