Bone turnover across the menopause transition : The role of gonadal inhibins.
Bone turnover across the menopause transition : The role of gonadal inhibins.
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DOI：
10.1111/j.1749-6632.2009.05349.x
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发表时间：
2010-03
影响因子：
5.2
通讯作者：
Gaddy D
中科院分区：
文献类型：
--
作者：
Nicks KM;Fowler TW;Akel NS;Perrien DS;Suva LJ;Gaddy D
越来越多的证据表明，绝经前妇女的骨转换和骨丢失增加，血清雌二醇水平降低。促卵泡激素水平升高与某些围绝经期变化相关。然而，转化生长因子（TGF）-β超家族的性腺促性腺激素的减少与绝经过渡期骨形成和吸收标志物的增加密切相关，并可预测围绝经期妇女的腰椎骨量，这可能是由于促性腺激素直接抑制成骨细胞和破骨细胞生成的结果。抑制素在成骨细胞和破骨细胞生成过程中特异性结合细胞。它们可以阻断骨形态发生蛋白（BMP）刺激的成骨细胞和破骨细胞发育以及BMP刺激的SMAD 1磷酸化，可能是通过BMP II型受体（BMPRII）的β-聚糖螯合。有趣的是，在小鼠体内持续暴露于Bibin A是合成代谢的，并对性腺切除诱导的骨丢失具有保护作用，这表明Bibin通过双模式作用机制促进骨代谢的内分泌调节，即周期性Bibin暴露抑制骨转换，而持续暴露于Bibin是合成代谢的。
Accumulating evidence demonstrates increasing bone turnover and bone loss in women prior to menopause and decreases in serum estradiol levels. Increased follicle-stimulating hormone levels have been correlated with some of these peri-menopausal changes. However, decreases in gonadal inhibins of the transforming growth factor (TGF)-β superfamily strongly correlate with increases in bone formation and resorption markers across the menopause transition and predict lumbar bone mass in peri-menopausal women, likely as a result of direct inhibin suppression of osteoblastogenesis and osteoclastogenesis. Inhibins bind specifically to cells during osteoblastogenesis and osteoclastogenesis. They can block bone morphogenetic protein (BMP)-stimulated osteoblast and osteoclast development as well as BMP-stimulated SMAD1 phosphorylation, likely via inhibin–β-glycan sequestration of BMP Type II receptor (BMPRII). Interestingly, continuous in vivo exposure to inhibin A is anabolic and protective against gonadectomyinduced bone loss in mice, suggesting that inhibins contribute to the endocrine regulation of bone metabolism via a bimodalmechanism of action whereby cycling inhibin exposure suppresses bone turnover and continuous exposure to inhibins is anabolic.
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