HB-EGF: a unique mediator of embryo-uterine interactions during implantation.

HB-EGF: a unique mediator of embryo-uterine interactions during implantation.
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DOI:
10.1016/j.yexcr.2008.07.025
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发表时间:
2009-02-15
影响因子:
3.7
通讯作者:
Dey SK
Dey SK
中科院分区:
医学3区
文献类型:
--
作者:
Lim HJ;Dey SK

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一个有发育能力的胚泡,在其附着在子宫壁上的几个小时之前,将信号传递给周围的子宫细胞,反之亦然,以启动双向相互作用。这种早熟的对话语言是多功能的,利用分泌的分子进行远程相互作用,利用膜结合的分子进行更直接的相互作用。肝素结合表皮生长因子样生长因子(HB-EGF)被确定为植入的早期信使,使用两种通信模式。在这篇综述中,我们讨论了HB-EGF的足迹,它最初是如何被确定为植入的介质,以及它如何在这个过程中启动胚胎-子宫相互作用。
An implantation-competent blastocyst, several hours prior to its attachment on the uterine wall, transmits signals to surrounding uterine cells and vice-versa to initiate a two-way interaction. The language of this precocious dialogue is versatile, taking advantage of secreted molecules for long-range interactions and membrane-bound molecules for more immediate interactions. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) was identified as an early messenger of implantation which uses both modes of communication. In this review, we discuss the footprint of HB-EGF as to how it was initially identified as a mediator of implantation and how it initiates embryo-uterine interactions during this process.
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