HB-EGF: a unique mediator of embryo-uterine interactions during implantation.
HB-EGF: a unique mediator of embryo-uterine interactions during implantation.
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DOI:
10.1016/j.yexcr.2008.07.025
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发表时间:
2009-02-15
影响因子:
3.7
通讯作者:
Dey SK
中科院分区:
文献类型:
--
作者:
Lim HJ;Dey SK
An implantation-competent blastocyst, several hours prior to its attachment on the uterine wall, transmits signals to surrounding uterine cells and vice-versa to initiate a two-way interaction. The language of this precocious dialogue is versatile, taking advantage of secreted molecules for long-range interactions and membrane-bound molecules for more immediate interactions. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) was identified as an early messenger of implantation which uses both modes of communication. In this review, we discuss the footprint of HB-EGF as to how it was initially identified as a mediator of implantation and how it initiates embryo-uterine interactions during this process.
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DOI:
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