Effects of Sound Interventions on the Permeability of the Blood-Brain Barrier and Meningeal Lymphatic Clearance.
Effects of Sound Interventions on the Permeability of the Blood-Brain Barrier and Meningeal Lymphatic Clearance.
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DOI：
10.3390/brainsci12060742
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发表时间：
2022-06-05
期刊：
影响因子：
3.3
通讯作者：
中科院分区：
文献类型：
--
作者：
脑膜淋巴或胶质淋巴系统正受到科学界越来越多的关注。最近的工作包括非侵入性技术，以证明血脑屏障（BBB）活动和人类中枢神经系统中的胶质淋巴系统之间的关系。一种潜在的技术是使用音乐/声音来增强关于小分子进出大脑的运动的BBB渗透性。然而，关于音乐/声音对BBB渗透性和胶质淋巴清除的使用的系统研究以及这些研究的结果的知识很少。这篇综述包含了讨论音乐/声音、血脑屏障通透性和脑膜淋巴清除之间关系的证据。概述了该系统的解剖学和生理学。我们讨论了音乐/声音的使用来调节大脑和身体功能，突出音乐对情绪和自主神经，认知和神经功能的影响。我们还提出了对后续工作的影响。结果表明，音乐和声音干预确实有助于BBB的开放，并随后增加脑膜淋巴系统的功能。证据还表明，音乐/声音有能力减少脑损伤的附带影响。不幸的是，音乐/声音很少在临床环境中作为医疗干预使用。尽管如此，最近的研究表明音乐/声音可能对各种器官系统产生潜在的积极影响。
The meningeal lymphatic, or glymphatic, system is receiving increasing attention from the scientific community. Recent work includes noninvasive techniques to demonstrate relationships between blood–brain barrier (BBB) activity and the glymphatic system in the human central nervous system. One potential technique is the use of music/sound to enhance BBB permeability regarding the movement of small molecules in and out of the brain. However, there is minimal knowledge regarding the methodical investigation(s) of the uses of music/sound on BBB permeability and glymphatic clearance and the outcomes of these investigation(s). This review contains evidence discussing relationships between music/sound, BBB permeability, and meningeal lymphatic clearance. An overview of the anatomy and physiology of the system is presented. We discuss the uses of music/sound to modulate brain and body functions, highlighting music’s effects on mood and autonomic, cognitive, and neuronal function. We also propose implications for follow-up work. The results showed that music and sound interventions do, in fact, contribute to the opening of the BBB and subsequently increase the function of the meningeal lymphatic system. Evidence also suggests that music/sound has the ability to reduce the collateral effects of brain injuries. Unfortunately, music/sound is rarely used in the clinical setting as a medical intervention. Still, recent research shows the potential positive impacts that music/sound could have on various organ systems.
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