The Subventricular Zone, a Hideout for Adult and Pediatric High-Grade Glioma Stem Cells.
The Subventricular Zone, a Hideout for Adult and Pediatric High-Grade Glioma Stem Cells.
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DOI：
10.3389/fonc.2020.614930
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发表时间：
2020
影响因子：
4.7
通讯作者：
Coppieters N
中科院分区：
文献类型：
--
作者：
Lombard A;Digregorio M;Delcamp C;Rogister B;Piette C;Coppieters N
在成人和儿童中，高级别胶质瘤(世卫组织III级和IV级)在癌症死亡中所占比例很高。这种不良的预后是肿瘤在几个月内复发的直接后果，尽管采取了包括手术切除、化疗和放射治疗在内的多种治疗方法。越来越多的证据表明，胶质瘤干细胞(GSCs)有助于肿瘤复发。事实上，GSCs可以从肿瘤块中迁移出来，到达脑室下区(SVZ)，这是一个在出生后持续存在的神经源性缝隙。一旦在SVZ中筑巢，GSCs就可以逃脱手术干预并抵抗治疗。本综述将定义神经干细胞，并描述它们与神经干细胞的相似性，神经干细胞是SVZ的居民。SVZ的建筑组织将同时针对人类和啮齿动物进行描述。下文还将描述GSC到达SVZ所采取的迁徙路线以及它们迁徙所涉及的信号通路。此外，我们将讨论SVZ为GSCs提供的微环境的优势，以及这如何有助于肿瘤复发。最后，我们将讨论SVZ在成人GBM和儿童HGG中的临床相关性，以及在这两种临床情况下靶向该神经源性区域的治疗优势。
Both in adult and children, high-grade gliomas (WHO grades III and IV) account for a high proportion of death due to cancer. This poor prognosis is a direct consequence of tumor recurrences occurring within few months despite a multimodal therapy consisting of a surgical resection followed by chemotherapy and radiotherapy. There is increasing evidence that glioma stem cells (GSCs) contribute to tumor recurrences. In fact, GSCs can migrate out of the tumor mass and reach the subventricular zone (SVZ), a neurogenic niche persisting after birth. Once nested in the SVZ, GSCs can escape a surgical intervention and resist to treatments. The present review will define GSCs and describe their similarities with neural stem cells, residents of the SVZ. The architectural organization of the SVZ will be described both for humans and rodents. The migratory routes taken by GSCs to reach the SVZ and the signaling pathways involved in their migration will also be described hereafter. In addition, we will debate the advantages of the microenvironment provided by the SVZ for GSCs and how this could contribute to tumor recurrences. Finally, we will discuss the clinical relevance of the SVZ in adult GBM and pediatric HGG and the therapeutic advantages of targeting that neurogenic region in both clinical situations.
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影响因子：
3.4
作者：
Barry G;Guennewig B;Fung S;Kaczorowski D;Weickert CS
通讯作者：
Weickert CS
影响因子：
5.2
作者：
Bar, Eli E.;Chaudhry, Aneeka;Eberharta, Charles G.
通讯作者：
Eberharta, Charles G.
影响因子：
15.9
作者：
Blough, Michael D.;Westgate, Morgan R.;Cairncross, J. Gregory
通讯作者：
Cairncross, J. Gregory
影响因子：
--
作者：
Brescia P;Richichi C;Pelicci G
通讯作者：
Pelicci G
DOI：
10.1186/1748-717x-9-95
发表时间：
2014-04-23
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
Adeberg S;Bostel T;König L;Welzel T;Debus J;Combs SE
通讯作者：
Combs SE