Stroma in breast development and disease.
Stroma in breast development and disease.
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DOI：
10.1016/j.semcdb.2009.10.003
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发表时间：
2010-02
影响因子：
7.3
通讯作者：
Kuperwasser C
中科院分区：
文献类型：
--
作者：
Arendt LM;Rudnick JA;Keller PJ;Kuperwasser C
越来越明显的是，正常和恶性乳腺组织的发展和进展需要复杂的局部和全身基质相互作用。在发育过程中，乳腺细胞的命运特化和分化需要来自基质的高度调节的背景信号。同样，在乳腺癌发展过程中，组织间质可以提供肿瘤抑制和肿瘤促进环境，用于调节上皮的肿瘤生长。本文综述了间质作为正常乳腺发育的介体，以及乳腺癌恶性转化和进展的关键调节因子的作用。认识到基质在乳腺癌进展过程中的重要作用，为治疗初始乳腺癌病变以及预防复发提供了新的靶点。
It is increasingly apparent that normal and malignant breast tissues require complex local and systemic stromal interactions for development and progression. During development, mammary cell fate specification and differentiation require highly regulated contextual signals derived from the stroma. Likewise, during breast carcinoma development, the tissue stroma can provide tumor suppressing and tumor-promoting environments that serve to regulate neoplastic growth of the epithelium. This review focuses on the role of the stroma as a mediator of normal mammary development, as well as a critical regulator of malignant conversion and progression in breast cancer. Recognition of the important role of the stroma during the progression of breast cancers leads to the possibility of new targets for treatment of the initial breast cancer lesion as well as prevention of recurrence.
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