Metabolism impacts upon Candida immunogenicity and pathogenicity at multiple levels.
Metabolism impacts upon Candida immunogenicity and pathogenicity at multiple levels.
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DOI：
10.1016/j.tim.2014.07.001
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发表时间：
2014-11
影响因子：
15.9
通讯作者：
Gow, Neil A. R.
中科院分区：
文献类型：
--
作者：
Brown, Alistair J. P.;Brown, Gordon D.;Netea, Mihai G.;Gow, Neil A. R.
关键词：
代谢适应在多个水平上影响白念珠菌的致病性。碳源影响毒力因子表达和先天免疫监视。营养素也影响抗应激和抗真菌药物的敏感性。念珠菌的致病性和免疫原性，因此必须不同的主机生态位。白色念珠菌是人类的主要真菌病原体，代谢是其致病性的组成部分。代谢适应不仅为不同寄主生态位的营养物质同化和生长提供了平台，而且还影响了C.白念珠菌宿主施加的压力和抗真菌药物，表达的关键毒力因子，和真菌的先天免疫防御的脆弱性。这些效应由连接代谢、形态发生、应激适应和细胞壁重塑的复杂调控网络驱动，影响着寄生虫和感染。因此，目前的概念，寄生虫-宿主相互作用必须扩展到包括代谢适应的影响，致病性和免疫原性。
Metabolic adaptation impacts upon Candida albicans pathogenicity at multiple levels. Carbon sources influence virulence factor expression and innate immune surveillance. Nutrients also affect stress resistance and antifungal drug susceptibility. Candida pathogenicity and immunogenicity therefore must differ between host niches. Metabolism is integral to the pathogenicity of Candida albicans, a major fungal pathogen of humans. As well as providing the platform for nutrient assimilation and growth in diverse host niches, metabolic adaptation affects the susceptibility of C. albicans to host-imposed stresses and antifungal drugs, the expression of key virulence factors, and fungal vulnerability to innate immune defences. These effects, which are driven by complex regulatory networks linking metabolism, morphogenesis, stress adaptation, and cell wall remodelling, influence commensalism and infection. Therefore, current concepts of Candida–host interactions must be extended to include the impact of metabolic adaptation upon pathogenicity and immunogenicity.
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影响因子：
6.7
作者：
Brothers KM;Gratacap RL;Barker SE;Newman ZR;Norum A;Wheeler RT
通讯作者：
Wheeler RT
影响因子：
3.4
作者：
Barelle CJ;Priest CL;Maccallum DM;Gow NA;Odds FC;Brown AJ
通讯作者：
Brown AJ
影响因子：
6.7
作者：
Citiulo F;Jacobsen ID;Miramón P;Schild L;Brunke S;Zipfel P;Brock M;Hube B;Wilson D
通讯作者：
Wilson D
DOI：
10.1242/jeb.088930
发表时间：
2014-01-01
期刊：
The Journal of experimental biology
影响因子：
--
作者：
Brown AJ;Budge S;Kaloriti D;Tillmann A;Jacobsen MD;Yin Z;Ene IV;Bohovych I;Sandai D;Kastora S;Potrykus J;Ballou ER;Childers DS;Shahana S;Leach MD
通讯作者：
Leach MD
影响因子：
2.1
作者：
CRITCHLEY, IA;DOUGLAS, LJ
通讯作者：
DOUGLAS, LJ