β-catenin overexpression in the nucleus predicts progress disease and unfavourable survival in colorectal cancer: a meta-analysis.
β-catenin overexpression in the nucleus predicts progress disease and unfavourable survival in colorectal cancer: a meta-analysis.
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DOI：
10.1371/journal.pone.0063854
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Huang J
中科院分区：
文献类型：
--
作者：
Chen Z;He X;Jia M;Liu Y;Qu D;Wu D;Wu P;Ni C;Zhang Z;Ye J;Xu J;Huang J
β-连环蛋白在结直肠癌的发生发展中起关键作用。然而，它对结直肠癌患者的预后意义仍然存在争议。采用相同的检索策略检索PubMed、Embase和Web of Science数据库中的相关文献。分析β-连环蛋白的表达与临床病理特征及预后的关系。共有18项研究符合纳入标准，包括3665例病例。Meta分析显示，β-连环蛋白的过度表达与结直肠癌患者的无病生存期(n = 541 in 3个研究；HR = 1.87，95%CI：1.2 8~2.71；Z = 3.2 6；P = 0.001)和总生存期(n = 2 630 in 10个研究；HR = 1.5 5，95%CI：1.12~2.14；Z = 2.62；P = 0.009)显著相关。β-连环蛋白胞浆表达与OS无明显相关性(n = 13 2 7，HR = 1.0 4，95%CI：0.88~1.2 4，Z = 0.46，P = 0.643)。β-连环蛋白在细胞核的联合优势比(OR)显示，β-连环蛋白过表达与晚期结直肠癌(n = 95 0，OR = 0.71，95%CI：0.5 3~0.94；Z = 2.35；P = 0.019)和转移(n = 628，5个研究；OR = 0.49，95%CI：0.2 5~0.96，Z = 2.06，P = 0.039)有关。β-catenin在细胞核中的过度表达与肿瘤部位(结肠或直肠)、分化程度、淋巴结状况及侵袭深度无关。合并OR值分别为1.0 9(95%CI：0.4 1~2.91，Z = 0.18，P = 0.856)，1.2 7(95%CI：0.76~2.10，Z = 0.92，P = 0.357)，0.71(95%CI：0.46~1.0 9，Z = 1.5 8，P = 0.115)和0.82(95%CI：0.4~1.68，Z = 0.53，P = 0.594)。这项研究表明，β-连环蛋白在细胞核中的过度表达，而不是在细胞质中的过度表达，似乎与结直肠癌患者的疾病进展和预后不良有关。
β-catenin plays a key role in the progression of colorectal cancer (CRC). However, its prognostic significance for patients with CRC remains controversial. Identical search strategies were used to search relevant literatures in the PubMed, Embase and Web of Science databases. The correlation between β-catenin expression and clinicopathological features and prognosis was analyzed. A total of 18 studies met the inclusion criteria, which comprised 3665 cases. Meta-analysis suggested that β-catenin overexpression in the nucleus was significantly associated with disease free survival (DFS) (n = 541 in 3 studies; HR = 1.87, 95% CI: 1.28–2.71; Z = 3.26; P = 0.001) and overall survival (OS) for CRC patients (n = 2630 in 10 studies; HR = 1.55, 95% CI: 1.12–2.14; Z = 2.62; P = 0.009). However, there was no significant association between β-catenin expression in the cytoplasm and OS (n = 1327 in 3 studies; HR = 1.04, 95% CI: 0.88–1.24, Z = 0.46, P = 0.643). The combined odds ratio (OR) of β-catenin in the nucleus indicated that β-catenin overexpression was associated with advanced stage CRC (n = 950 in 7 studies; OR = 0.71, 95% CI: 0.53–0.94; Z = 2.35; P = 0.019) and metastasis of CRC (n = 628 in 5 studies; OR = 0.49, 95% CI: 0.25–0.96, Z = 2.06, P = 0.039). β-catenin overexpression in the nucleus had no correlation with the tumor site (colon or rectum), differentiation grade, lymph node status or depth of invasion. The pooled ORs were 1.09 (95% CI: 0.41–2.91, Z = 0.18, P = 0.856), 1.27(95% CI: 0.76–2.10, Z = 0.92, P = 0.357), 0.71(95% CI: 0.46–1.09, Z = 1.58, P = 0.115) and 0.82(95% CI: 0.4–1.68, Z = 0.53, P = 0.594). This study showed that β-catenin overexpression in the nucleus, rather than in the cytoplasm, appeared to be associated with progress disease and a worse prognosis for CRC patients.
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影响因子：
29.4
作者：
Ougolkov, AV;Yamashita, K;Minamoto, T
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