Test-retest stability of calibrated BOLD-fMRI in HIV- and HIV+ subjects.
Test-retest stability of calibrated BOLD-fMRI in HIV- and HIV+ subjects.
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DOI：
10.1016/j.neuroimage.2010.09.081
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发表时间：
2011-02-01
期刊：
影响因子：
5.7
通讯作者：
Buxton R
中科院分区：
文献类型：
--
作者：
Ances B;Vaida F;Ellis R;Buxton R
受试者表现、扫描仪硬件或生物学因素可能会影响单次神经成像测量。使用校准血氧水平依赖性功能磁共振成像（BOLD-fMRI）的稳定性研究已在健康人群中进行，但未在疾病人群中进行。我们利用校准的BOLD-fMRI来确定HIV对神经血管耦合的影响。6名临床稳定的HIV感染患者（HIV+）和10名血清阴性对照（HIV-）在两个单独的时间间隔约3个月进行扫描。进行轻度高碳酸血症（5%CO2）暴露和视觉功能激活任务。针对HIV+和HIV−受试者，确定校准的BOLD-fMRI测量（基线脑血流量（CBF）、功能性CBF、BOLD和脑耗氧代谢率（CMRO 2）变化）的类内相关系数（ICC）和受试者间方差。两组在年龄、性别或教育程度上没有差异。HIV阳性受试者的平均基线CBF（p <0.04，Cohen's d=-1.07）和功能性BOLD反应（p< 0.001，Cohen's d=-2.47）较低，尽管平均功能性CMRO 2变化相似（p = 0.71，Cohen's d=0.19），但平均功能性CBF反应呈下降趋势（p= 0.07，Cohen's d=-0.92）。ICC评估的每个校准BOLD-fMRI测量的稳定性对于HIV+受试者显著较低。此外，HIV阳性受试者的基线CBF（p <0.02）、功能BOLD（p< 0.001）、CBF（p<0.001）和CMRO 2（p< 0.002）反应的受试者间变异性更大。我们的研究结果表明，校准的BOLD-fMRI措施在健康对照组具有良好的稳定性。相比之下，这些值在临床稳定的HIV+受试者中具有更大的变异性，并且可以反映CBF和CMRO 2与疾病之间的耦合的改变。
Subject performance, scanner hardware, or biological factors can affect single session neuroimaging measures. Stability studies using calibrated blood oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI) have been performed in health but not disease. We utilized calibrated BOLD-fMRI to determine the effects of HIV on neurovascular coupling. 6 clinically stable HIV-infected patients (HIV+) and 10 seronegative controls (HIV−) were scanned at two separate sessions approximately 3 months apart. Both mild hypercapnia (5% CO2) exposure and a visual functional activation task were performed. Intra-class correlation coefficients (ICC) and inter-subject variance were determined for calibrated BOLD-fMRI measures (baseline cerebral blood flow (CBF), functional CBF, BOLD, and cerebral metabolic rate of oxygen consumption (CMRO2) changes) for HIV+ and HIV− subjects. The two groups did not differ in age, sex, or education. HIV+ subjects had lower mean baseline CBF (p <0.04, Cohen’s d=−1.07) and functional BOLD responses (p< 0.001, Cohen’s d=−2.47) and a trend towards a decrease in mean functional CBF responses (p= 0.07, Cohen’s d=−0.92) despite similar mean functional CMRO2 changes (p= 0.71, Cohen’s d=0.19). The stability of each calibrated BOLD-fMRI measure, as assessed by ICC, was significantly lower for HIV+ subjects. In addition, HIV+ participants had greater inter-subject variability for baseline CBF (p <0.02), functional BOLD (p< 0.001), CBF (p< 0.001), and CMRO2 (p< 0.002) responses. Our results demonstrate that calibrated BOLD-fMRI measures have excellent stability within healthy controls. In contrast, these values have greater variability in clinically stable HIV+ subjects and may reflect alterations in coupling between CBF and CMRO2 with disease.
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DOI：
10.3389/fnene.2010.00008
发表时间：
2010
期刊：
Frontiers in neuroenergetics
影响因子：
--
作者：
Buxton RB
通讯作者：
Buxton RB
神经影像学方法的新功能？
影响因子：
5.2
作者：
Bandettini PA
通讯作者：
Bandettini PA
影响因子：
9.9
作者：
Ances, BM;Roc, AC;Detre, JA
通讯作者：
Detre, JA
影响因子：
5.7
作者：
Goodwin, Jonathan A.;Vidyasagar, Rishma;Parkes, Laura M.
通讯作者：
Parkes, Laura M.
影响因子：
8.3
作者：
GRUBB, RL;RAICHLE, ME;TERPOGOS.MM
通讯作者：
TERPOGOS.MM