Resistin, visfatin, adiponectin, and leptin: risk of breast cancer in pre- and postmenopausal saudi females and their possible diagnostic and predictive implications as novel biomarkers.
Resistin, visfatin, adiponectin, and leptin: risk of breast cancer in pre- and postmenopausal saudi females and their possible diagnostic and predictive implications as novel biomarkers.
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DOI：
10.1155/2015/253519
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Hassanien MF
中科院分区：
文献类型：
--
作者：
Assiri AM;Kamel HF;Hassanien MF
肥胖诱发乳腺癌的机制尚不清楚。一种假设是，高水平的脂肪因子可以促进乳腺癌(BC)的发展。本研究的目的是在绝经前和绝经后的女性中调查抵抗素、内脂素、脂联素和瘦素与BC风险的相关性。共纳入82例新诊断和组织学确诊的BC患者和68例年龄和BMI匹配的健康对照。两组均被细分为绝经后和绝经前两个亚组。用双抗体夹心法测定抵抗素、内脂素、脂联素和瘦素。绝经后BC患者的瘦素、抵抗素和内脂素水平显著高于他们各自的对照组。仅在绝经后亚组中，瘦素、抵抗素和内脂素水平与TNM分期、肿瘤大小、淋巴结转移和组织学分级呈正相关。在绝经后女性中，多因素Logistic回归分析显示，脂联素、瘦素、内脂素和抵抗素是BC的危险因素。我们的结果提示，血清抵抗素、瘦素、脂联素和内脂素水平作为绝经后乳腺癌的危险因素，可能与临床病理特征有潜在的联系，有望成为绝经后乳腺癌的新的生物标志物。
The mechanisms of obesity-induced breast carcinogenesis are not clear. One hypothesis is that high levels of adipokines could promote breast cancer (BC) development. The aim of this study was to investigate the correlation of resistin, visfatin, adiponectin, and leptin with BC risk in pre- and postmenopausal females. A total of 82 BC newly diagnosed and histologically confirmed patients and 68 age and BMI matched healthy controls were enrolled. Both groups were subdivided into post- and premenopausal subgroups. Resistin, visfatin, adiponectin, and leptin were measured by ELISA. There were significantly higher levels of leptin, resistin, and visfatin in postmenopausal BC patients than their respective controls. Only in postmenopausal subgroups, leptin, resistin, and visfatin levels were positively correlated with TNM staging, tumor size, lymph node (LN) metastasis, and histological grading. In postmenopausal females, multivariate logistic regression analysis revealed that adiponectin, leptin, visfatin, and resistin were risk factors for BC. Our results suggested that serum resistin, leptin, adiponectin, and visfatin levels as risk factors for postmenopausal BC may provide a potential link with clinicopathological features and are promising to be novel biomarkers for postmenopausal BC.
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DOI：
10.1016/j.jsbmb.2006.09.040
发表时间：
2007-04-01
影响因子：
4.1
作者：
Geisler, Juergen;Haynes, Ben;Lonning, Per Eystein
通讯作者：
Lonning, Per Eystein
影响因子：
4.5
作者：
Kang JH;Yu BY;Youn DS
通讯作者：
Youn DS
DOI：
10.1093/jnci/djh216
发表时间：
2004-08-04
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Furberg, AS;Veierod, MB;Thune, I
通讯作者：
Thune, I
影响因子：
3.8
作者：
Kim, Jae Geun;Kim, Eun Ok;Lee, Byung Ju
通讯作者：
Lee, Byung Ju
影响因子：
3.3
作者：
James, Rebecca E.;Lukanova, Annekatrin;Kaaks, Rudolf
通讯作者：
Kaaks, Rudolf