Two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) in Japan: a pathognomonic histological feature and unique complication of SFTS.

Two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) in Japan: a pathognomonic histological feature and unique complication of SFTS.
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DOI:
10.1111/pin.12207
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发表时间:
2014-11
影响因子:
2.2
通讯作者:
Yonezawa S
Yonezawa S
中科院分区:
医学4区
文献类型:
--
作者:
Hiraki T;Yoshimitsu M;Suzuki T;Goto Y;Higashi M;Yokoyama S;Tabuchi T;Futatsuki T;Nakamura K;Hasegawa H;Saijo M;Kakihana Y;Arima N;Yonezawa S

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我们报告两例尸检严重发热伴血小板减少综合征(SFTS)与高死亡率的老年日本患者。这两起案件都是由蜱虫咬伤引起的。其特征性组织学表现为全身淋巴组织坏死性淋巴结炎,伴有SFTS病毒和SFTSV-RNA拷贝。在两名患者的肺部也观察到明显的真菌感染。由于SFTS患者的细胞免疫功能可能受到抑制,因此医生应注意可能的真菌感染。
We report two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) with a high fatality rate in aged Japanese patients. Both cases were caused by a tick-bite. The pathognomonic histological feature was necrotizing lymphadenitis of systemic lymphoid tissue with SFTS viruses and SFTSV-RNA copies. Marked fungal infections were also observed in the lungs of both patients. Since cellular immune function may be suppressed in SFTS patients, physicians should be aware of possible fungal infections.
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