A new perspective of vasculogenic mimicry: EMT and cancer stem cells (Review).
A new perspective of vasculogenic mimicry: EMT and cancer stem cells (Review).
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DOI:
10.3892/ol.2013.1555
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发表时间:
2013-11
期刊:
影响因子:
2.9
通讯作者:
Liang XH
中科院分区:
文献类型:
--
作者:
Fan YL;Zheng M;Tang YL;Liang XH
Vasculogenic mimicry (VM), a new pattern of tumor microcirculation, is important for the growth and progression of tumors. Epithelial-mesenchymal transition (EMT) is pivotal in malignant tumor progression and VM formation. With increasing knowledge of cancer stem cell (CSC) phenotypes and functions, increasing evidence suggests that CSCs are involved in VM formation. Recent studies have indicated that EMT is relevant to the acquisition and maintenance of stem cell-like characteristics. Thus, in this review we discuss the correlation between CSCs, EMT and VM formation.
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