A new perspective of vasculogenic mimicry: EMT and cancer stem cells (Review).

A new perspective of vasculogenic mimicry: EMT and cancer stem cells (Review).
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DOI:
10.3892/ol.2013.1555
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发表时间:
2013-11
期刊:
影响因子:
2.9
通讯作者:
Liang XH
Liang XH
中科院分区:
医学4区
文献类型:
--
作者:
Fan YL;Zheng M;Tang YL;Liang XH

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血管生成拟态(vasculogenicmimicry,VM)是一种新的肿瘤微循环模式,对肿瘤的生长和发展具有重要意义。上皮间质转化(EMT)是恶性肿瘤进展和VM形成的关键。随着对癌症干细胞(CSC)表型和功能的了解越来越多,越来越多的证据表明CSC参与VM的形成。最近的研究表明,EMT与干细胞样特征的获得和维持有关。因此,在这篇综述中,我们讨论了CSC、EMT和VM形成之间的相关性。
Vasculogenic mimicry (VM), a new pattern of tumor microcirculation, is important for the growth and progression of tumors. Epithelial-mesenchymal transition (EMT) is pivotal in malignant tumor progression and VM formation. With increasing knowledge of cancer stem cell (CSC) phenotypes and functions, increasing evidence suggests that CSCs are involved in VM formation. Recent studies have indicated that EMT is relevant to the acquisition and maintenance of stem cell-like characteristics. Thus, in this review we discuss the correlation between CSCs, EMT and VM formation.
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