Two-channel recording of auditory-evoked potentials to detect age-related deficits in temporal processing.
Two-channel recording of auditory-evoked potentials to detect age-related deficits in temporal processing.
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DOI：
10.1016/j.heares.2012.04.014
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发表时间：
2012-07
期刊：
影响因子：
2.8
通讯作者：
Bartlett E
中科院分区：
文献类型：
--
作者：
Parthasarathy A;Bartlett E
听觉脑干反应（ABR）以及包络和频率跟随反应（EFR 和 FFR）被广泛用于研究衰老等条件下的异常听觉处理。我们之前曾使用从单个通道记录的 EFR 报告过快速调幅 (AM) 频率的听觉处理中与年龄相关的缺陷。然而，需要对大范围调制频率的 EFR 进行灵敏测试，才能更全面地了解听觉处理缺陷。在这项研究中，从年轻和年老 Fischer-344 大鼠（一种常见的听觉衰老模型）的两个电极配置中同时记录了 ABR 和 EFR。分析表明，这两个通道对互补 AM 频率的响应最敏感。从 Fz 到乳突记录的通道 1，对 100–700 Hz 频率范围内的较快 AM 频率响应更好，而从耳间线到乳突记录的通道 2，对 16–100 Hz 范围内的较慢 AM 频率响应更好。使用具有不同声级和调制深度的 AM 刺激同时记录通道 1 和 2 表明，与年龄相关的时间处理缺陷在较慢的 AM 频率下不存在，而仅在较快的 AM 频率下出现，而单独从任一通道记录时不会出现明显的情况。对幼年动物未麻醉和异氟烷麻醉记录之间的 EFR 进行比较，以及与之前发表的 ABR 波形进行比较，表明通道 1 的发生器可能更强调尾部脑干结构，而通道 2 的发生器可能更强调头侧听觉核，包括下丘和前脑，分离边界可能沿着耳蜗核/上橄榄复合体。 EFR 的同时两通道记录有助于更全面地了解各种调制频率下的听觉时间处理特性，这有助于理解正常、发育或病理条件下声音刺激的神经表征
Auditory brainstem responses (ABRs), and envelope and frequency following responses (EFRs and FFRs) are widely used to study aberrant auditory processing in conditions such as aging. We have previously reported age-related deficits in auditory processing for rapid amplitude modulation (AM) frequencies using EFRs recorded from a single channel. However sensitive testing of EFRs along a wide range of modulation frequencies is required to gain a more complete understanding of the auditory processing deficits. In this study, ABRs and EFRs were recorded simultaneously from two electrode configurations in young and old Fischer-344 rats, a common auditory aging model. Analysis shows that the two channels respond most sensitively to complementary AM frequencies. Channel 1, recorded from Fz to mastoid, responds better to faster AM frequencies in the 100–700 Hz range of frequencies, while Channel 2, recorded from the inter-aural line to the mastoid, responds better to slower AM frequencies in the 16–100 Hz range. Simultaneous recording of channels 1 and 2 using AM stimuli with varying sound levels and modulation depths show that age related deficits in temporal processing are not present at slower AM frequencies but only at more rapid ones, which would not have been apparent recording from either channel alone. Comparison of EFRs between unanesthetized and isoflurane anesthetized recordings in young animals, as well as comparison with previously published ABR waveforms, suggests that the generators of Channel 1 may emphasize more caudal brainstem structures while those of Channel 2 may emphasize more rostral auditory nuclei including the inferior colliculus and the forebrain, with the boundary of separation potentially along the cochlear nucleus/superior olivary complex. Simultaneous two channel recording of EFRs help to give a more complete understanding of the properties of auditory temporal processing over a wide range of modulation frequencies which is useful in understanding neural representations of sound stimuli in normal, developmental or pathological conditions
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DOI：
10.1007/s00359-007-0238-6
发表时间：
2007-08-01
影响因子：
2.1
作者：
Finneran, James J.;London, Hollis R.;Houser, Dorian S.
通讯作者：
Houser, Dorian S.
影响因子：
3.7
作者：
Anderson S;Parbery-Clark A;Yi HG;Kraus N
通讯作者：
Kraus N
影响因子：
2.8
作者：
Clinard CG;Tremblay KL;Krishnan AR
通讯作者：
Krishnan AR
影响因子：
56.9
作者：
BUCHWALD, JS;HUANG, CM
通讯作者：
HUANG, CM
DOI：
10.1044/jshd.5101.63
发表时间：
1986-02-01
期刊：
JOURNAL OF SPEECH AND HEARING DISORDERS
影响因子：
--
作者：
BEATTIE, RC;BEGUWALA, FE;BOYD, RL
通讯作者：
BOYD, RL