Infra-slow oscillation (ISO) of the pupil size of urethane-anaesthetised rats.
Infra-slow oscillation (ISO) of the pupil size of urethane-anaesthetised rats.
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DOI：
10.1371/journal.pone.0062430
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lewandowski MH
中科院分区：
文献类型：
--
作者：
Blasiak T;Zawadzki A;Lewandowski MH
在哺乳动物大脑的不同组织水平上，已经描述了在亚慢速频率（<0.01 Hz）范围内的振荡现象的多样性。许多脑亚慢振荡（ISO）的生理和/或行为的意义和表现仍然未知。这种现象的例子是在麻醉大鼠的大脑中观察到的两种类型的ISO：皮层下视觉系统的几个核团中动作电位放电速率的亚缓慢、有节奏的变化和EEG信号中可见的睡眠样激活/失活周期。由于这两种节律现象都涉及到可以影响自主神经系统活动的大脑网络，因此我们假设这两种大脑ISO可以通过瞳孔大小的节律变化来反映。因此，在本研究中，我们同时使用瞳孔描记术和ECoG记录，以验证假设存在的超慢振荡的瞳孔大小的麻醉大鼠。结果显示，麻醉大鼠的瞳孔大小和眼球运动有节律地变化。所观察到的节奏的特点是由两个不同的主导成分在一个范围内的亚慢频率。第一，长成分的周期为2.29分钟，并且在虹膜和眼球运动中都存在。第二，短成分的周期为1.22分钟，并且仅在瞳孔的节律性收缩和扩张中观察到。两个ISO同时存在于双眼中，并且它们在左眼和右眼之间同步。长ISO分量与大脑状态的周期性交替同步，如ECoG信号模式的节律性变化所揭示的。基于所获得的结果，我们提出了一个模型的干扰ISO存在于不同的大脑系统参与控制瞳孔大小。
Multiplicity of oscillatory phenomena in a range of infra-slow frequencies (<0.01 Hz) has been described in mammalian brains at different levels of organisation. The significance and manifestation in physiology and/or behaviour of many brain infra-slow oscillations (ISO) remain unknown. Examples of this phenomenon are two types of ISO observed in the brains of urethane-anaesthetised rats: infra-slow, rhythmic changes in the rate of action potential firing in a few nuclei of the subcortical visual system and a sleep-like cycle of activation/deactivation visible in the EEG signal. Because both of these rhythmic phenomena involve brain networks that can influence autonomic nervous system activity, we hypothesised that these two brain ISOs can be reflected by rhythmic changes of pupil size. Thus, in the present study, we used simultaneous pupillography and ECoG recording to verify the hypothesised existence of infra-slow oscillations in the pupil size of urethane-anaesthetised rats. The obtained results showed rhythmic changes in the size of the pupils and rhythmic eyeball movements in urethane-anaesthetised rats. The observed rhythms were characterised by two different dominant components in a range of infra-slow frequencies. First, the long component had a period of ≈29 minutes and was present in both the irises and the eyeball movements. Second, the short component had a period of ≈2 minutes and was observed only in the rhythmic constrictions and dilations of the pupils. Both ISOs were simultaneously present in both eyes, and they were synchronised between the left and right eye. The long ISO component was synchronised with the cyclic alternations of the brain state, as revealed by rhythmic changes in the pattern of the ECoG signal. Based on the obtained results, we propose a model of interference of ISO present in different brain systems involved in the control of pupil size.
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影响因子：
3
作者：
Blasiak, Tomasz;Czubak, Wojciech;Lewandowski, Marian H.
通讯作者：
Lewandowski, Marian H.
影响因子：
16.2
作者：
Lall, Gurprit S.;Revell, Victoria L.;Momiji, Hiroshi;Al Enezi, Jazi;Altimus, Cara M.;Gueler, Ali D.;Aguilar, Carlos;Cameron, Morven A.;Allender, Susan;Hankins, Mark W.;Lucas, Robert J.
通讯作者：
Lucas, Robert J.
影响因子：
3.3
作者：
Blasiak, T.;Lewandowski, M. H.
通讯作者：
Lewandowski, M. H.
DOI：
10.1073/pnas.0601417103
发表时间：
2006-09-12
影响因子：
11.1
作者：
Damoiseaux, J. S.;Rombouts, S. A. R. B.;Beckmann, C. F.
通讯作者：
Beckmann, C. F.
影响因子：
3.7
作者：
Clement EA;Richard A;Thwaites M;Ailon J;Peters S;Dickson CT
通讯作者：
Dickson CT