Microbial degradation of complex carbohydrates in the gut.
Microbial degradation of complex carbohydrates in the gut.
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DOI：
10.4161/gmic.19897
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发表时间：
2012-07
期刊：
影响因子：
12.2
通讯作者：
Forano E
中科院分区：
文献类型：
--
作者：
Flint HJ;Scott KP;Duncan SH;Louis P;Forano E
在哺乳动物肠道中定植的细菌，其降解酶和代谢能力比宿主菌要多得多。复杂的不可消化的膳食碳水化合物和宿主来源的聚糖在人体肠道中的微生物发酵对健康具有重要影响。某些优势物种，特别是拟杆菌，已知拥有非常大量的编码碳水化合物活性酶的基因，并且可以根据可用性在肠道中的不同能量来源之间容易地切换。然而，更多的营养专门化的细菌似乎在社区中发挥关键作用，通过启动复杂的底物，如植物细胞壁，淀粉颗粒和粘蛋白的降解。例如，厚壁菌门、放线菌门和疣微菌门正在出现，但需要更多关于这些研究较少的类群的信息。膳食碳水化合物（包括益生元）对人类健康的影响需要了解膳食组成、肠道微生物群和代谢产物之间的复杂关系。
Bacteria that colonize the mammalian intestine collectively possess a far larger repertoire of degradative enzymes and metabolic capabilities than their hosts. Microbial fermentation of complex non-digestible dietary carbohydrates and host–derived glycans in the human intestine has important consequences for health. Certain dominant species, notably among the Bacteroidetes, are known to possess very large numbers of genes that encode carbohydrate active enzymes and can switch readily between different energy sources in the gut depending on availability. Nevertheless, more nutritionally specialized bacteria appear to play critical roles in the community by initiating the degradation of complex substrates such as plant cell walls, starch particles and mucin. Examples are emerging from the Firmicutes, Actinobacteria and Verrucomicrobium phyla, but more information is needed on these little studied groups. The impact of dietary carbohydrates, including prebiotics, on human health requires understanding of the complex relationship between diet composition, the gut microbiota and metabolic outputs.
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影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
2.8
作者：
Aurilia, V;Martin, JC;Flint, HJ
通讯作者：
Flint, HJ
影响因子：
4.4
作者：
Barboza, Mariana;Sela, David A.;Lebrilla, Carlito B.
通讯作者：
Lebrilla, Carlito B.
影响因子：
4.2
作者：
Abell, Guy C. J.;Cooke, Caroline M.;McOrist, Alexandra L.
通讯作者：
McOrist, Alexandra L.
DOI：
10.1073/pnas.0806191105
发表时间：
2009-02-10
影响因子：
11.1
作者：
Brulc, Jennifer M.;Antonopoulos, Dionysios A.;White, Bryan A.
通讯作者：
White, Bryan A.