Potential role for magnetoencephalography in distinguishing low- and high-grade gliomas: a preliminary study with histopathological confirmation.
Potential role for magnetoencephalography in distinguishing low- and high-grade gliomas: a preliminary study with histopathological confirmation.
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脑磁图在区分低级别和高级别胶质瘤中的潜在作用：组织病理学证实的初步研究。
DOI：
10.1093/neuonc/nos064
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发表时间：
2012
期刊：
影响因子：
15.9
通讯作者：
Aizenberg,MicheleR
中科院分区：
文献类型：
--
作者：
Wilson,TonyW;Heinrichs-Graham,Elizabeth;Aizenberg,MicheleR
神经胶质瘤是中枢神经系统中最常见的肿瘤形式，并且异常异质。准确描述胶质瘤的分级和类型对于预测肿瘤进展速度至关重要。基于活检组织的组织学分级和分析仍然是金标准，但非侵入性和半侵入性神经成像也起着关键作用。几十年来，神经影像学一直被用于指导和优化活检，但最近分子成像和MRI的变体在独立预测胶质瘤分级方面显示出了希望。在这里，我们评估是否脑磁图（MEG）测量的人群水平的神经胶质瘤空间内的生理预测的固有等级的组织，基于明确的组织病理学分析。高密度MEG数据记录了11例患者，他们正在接受功能标测，为切除手术做准备。初步结果表明，胶质瘤分级与胶质瘤空间内θ（4 - 7 Hz）、α（8 - 14 Hz）和β带（14 - 30 Hz）中的局部活动幅度呈正相关。此外，相对于相同频带中未受影响的同源区域，胶质瘤内的活性显着升高。这些结果表明，病理水平的同步存在于肿瘤空间和MEG可能是一个可行的工具，非侵入性分化胶质瘤的等级。虽然这些结果应该被认为是初步的，只是在性质上的相关性，这些数据表明，MEG可以潜在地检测神经生理学的签名或标志物，预测神经胶质肿瘤的固有等级。
Gliomas are the most common form of tumor in the CNS and are exceptionally heterogeneous. Accurately characterizing gliomas, in terms of grade and type, is essential for predicting the rate of tumor progression. Histopathological grading and analysis based on biopsied tissue remains the gold standard, but non- and semi-invasive neuroimaging also plays a key role. Neuroimaging has been used to guide and optimize biopsies for several decades, but more recently molecular imaging and variants of MRI have shown promise in independently predicting glioma grade. Here we evaluated whether magnetoencephalographic (MEG) measurements of population-level physiology within the glioma space were predictive of the inherent grade of the tissue, based on definitive histopathological analyses. High-density MEG data were recorded from 11 patients who were undergoing functional mapping in preparation for resective surgery. The primary results indicated that glioma grade was positively correlated with the local amplitude of activity within the glioma space in the theta (4–7 Hz), alpha (8–14 Hz), and beta bands (14–30 Hz). Additionally, activity within the glioma was significantly elevated relative to the nonaffected homologue area in the same frequency bands. These results indicate that pathological levels of synchronization exist within the tumor space and that MEG may be a viable tool for noninvasively differentiating gliomas by their grade. Although these results should be considered preliminary and are only correlative in nature, these data suggest that MEG can potentially detect neurophysiological signatures or markers that predict the inherent grade of a glial tumor.
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影响因子：
56.9
作者：
GUILLEMIN, R;BRAZEAU, P;WEHRENBERG, WB
通讯作者：
WEHRENBERG, WB
未提取的人血浆中促肾上腺皮质激素的快速放射免疫测定。
影响因子：
9.3
作者：
Nicholson,WE;Davis,DR;Sherrell,BJ;Orth,DN
通讯作者：
Orth,DN
引起库欣病的垂体微腺瘤对促肾上腺皮质激素释放因子有反应。
DOI：
10.1210/jcem-55-5-1017
发表时间：
1982
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Orth,DN;DeBold,CR;DeCherney,GS;Jackson,RV;Alexander,AN;Rivier,J;Rivier,C;Spiess,J;Vale,W
通讯作者：
Vale,W
合成绵羊促肾上腺皮质激素释放因子的作用：延长血浆促肾上腺皮质激素和皮质醇的作用持续时间和双相反应。
DOI：
10.1210/jcem-57-2-294
发表时间：
1983
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
DeBold,CR;DeCherney,GS;Jackson,RV;Sheldon,WR;Alexander,AN;Island,DP;Rivier,J;Vale,W;Orth,DN
通讯作者：
Orth,DN
影响因子：
158.5
作者：
MERIMEE, TJ;RABINOWITZ, D;MCKUSICK, VA
通讯作者：
MCKUSICK, VA