KDM5B overexpression predicts a poor prognosis in patients with squamous cell carcinoma of the head and neck.
KDM5B overexpression predicts a poor prognosis in patients with squamous cell carcinoma of the head and neck.
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KDM5B 过表达预示头颈鳞状细胞癌患者预后不良
DOI：
10.7150/jca.22145
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发表时间：
2018
影响因子：
3.9
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Huang D;Qiu Y;Li G;Liu C;She L;Zhang D;Chen X;Zhu G;Zhang X;Tian Y;Liu Y
目的：赖氨酸脱甲基酶（KDM）5 B是组蛋白赖氨酸脱甲基酶家族的成员之一，在多种人类癌症中过度表达并异常发挥功能。然而，其在头颈部鳞状细胞癌（SCCHN）中的表达尚不清楚。研究方法：KDM 5 B表达通过免疫组织化学分析，并与103个档案SCCHN组织样本和24个相邻的非癌上皮组织的临床病理参数相关。结果：KDM 5 B在SCCHN中的表达明显高于癌旁组织。这与淋巴结转移和肿瘤复发密切相关。此外，Kaplan-Meier分析显示，KDM 5 B高表达患者的无病生存期和总生存期均短于KDM 5 B低表达患者。重要的是，单因素和多因素分析均表明KDM 5 B水平是SCCHN患者的独立预后因素。结论：这些结果表明，KDM 5 B是一个有价值的生物标志物，可用于预测SCCHN患者的结果。
Purpose: Lysine demethylase (KDM) 5B, as a member of the histone lysine demethylase family, is overexpressed and functions abnormally in various human cancers. However, its expression in the squamous cell carcinoma of the head and neck (SCCHN) remains unclear. Methods: KDM5B expression was analyzed by immunohistochemistry and correlated with clinicopathological parameters in 103 archival SCCHN tissue samples and 24 adjacent noncancerous epithelial tissues. Results: We found that KDM5B expression was higher in SCCHN than that in adjacent noncancerous tissues. This was closely associated with lymph node metastasis and tumor recurrence. In addition, Kaplan-Meier analysis revealed that patients with high KDM5B expression had shorter disease-free and overall survival times than those with low KDM5B expression. Importantly, both univariate and multivariate analysis demonstrated that KDM5B level was an independent prognostic factor in SCCHN patients. Conclusions: These results indicate that KDM5B is a valuable biomarker that can be used to predict SCCHN patient outcome.
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JARID1b的过表达与上皮卵巢癌的预后不良和化学疗法抗性有关。
影响因子：
--
作者：
Wang, Lishuang;Mao, Yuanfu;Du, Guiqin;He, Chunbo;Han, Shiyu
通讯作者：
Han, Shiyu
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影响因子：
16.6
作者：
Akbani, Rehan;Ng, Patrick Kwok Shing;Werner, Henrica M. J.;Shahmoradgoli, Maria;Zhang, Fan;Ju, Zhenlin;Liu, Wenbin;Yang, Ji-Yeon;Yoshihara, Kosuke;Li, Jun;Ling, Shiyun;Seviour, Elena G.;Ram, Prahlad T.;Minna, John D.;Diao, Lixia;Tong, Pan;Heymach, John V.;Hill, Steven M.;Dondelinger, Frank;Stadler, Nicolas;Byers, Lauren A.;Meric-Bernstam, Funda;Weinstein, John N.;Broom, Bradley M.;Verhaak, Roeland G. W.;Liang, Han;Mukherjee, Sach;Lu, Yiling;Mills, Gordon B.
通讯作者：
Mills, Gordon B.
组蛋白去甲基化酶 KDM5B 是基因组稳定性的关键调节因子
DOI：
10.1073/pnas.1324036111
发表时间：
2014-05-13
影响因子：
11.1
作者：
Li, Xin;Liu, Ling;Shi, Lei
通讯作者：
Shi, Lei
EphA2在头颈部鳞状细胞癌中表达的临床意义
DOI：
10.1007/s00432-010-0936-2
发表时间：
2011-05-01
影响因子：
3.6
作者：
Liu, Yong;Zhang, Xin;Tian, Yongquan
通讯作者：
Tian, Yongquan
影响因子：
14.9
作者：
He R;Kidder BL
通讯作者：
Kidder BL