Microbiome and Metabolome Analyses Reveal Novel Interplay Between the Skin Microbiota and Plasma Metabolites in Psoriasis.
Microbiome and Metabolome Analyses Reveal Novel Interplay Between the Skin Microbiota and Plasma Metabolites in Psoriasis.
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微生物组和代谢组分析揭示了皮肤微生物群和血浆代谢物之间的新相互作用。
DOI：
10.3389/fmicb.2021.643449
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发表时间：
2021
影响因子：
5.2
通讯作者：
Shi H
中科院分区：
文献类型：
--
作者：
Chen D;He J;Li J;Zou Q;Si J;Guo Y;Yu J;Li C;Wang F;Chan T;Shi H
Psoriasis is a chronic inflammatory skin disease that affects millions of people worldwide. There is still no effective approach for the clinical treatment of psoriasis. This is largely due to the lack of understanding of the pathological mechanism. Here, we comprehensively characterized the skin microbiome and plasma metabolome alterations of psoriasis patients. We observed that some pathogenic bacteria, including Vibrio, were significantly increased in psoriasis patients. The metabolomics results showed alterations in some metabolic pathways, especially pathways for lipid metabolism. In addition, microbiome-specific metabolites, including bile acids and kynurenine, were significantly changed. Correlation analysis revealed the interplay between the skin microbiota and plasma metabolites, especially between Vibrio and several lipids. Our results provide new evidence for the interplay between the skin microbiome and plasma metabolites, which is dramatically disrupted in psoriasis patients. This study also revealed the mechanism underlying the pathogenesis of psoriasis.
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影响因子：
5
作者：
Sergeant S;Rahbar E;Chilton FH
通讯作者：
Chilton FH
影响因子：
46.9
作者：
通讯作者：
--
影响因子：
3
作者：
Mrowietz U;Kragballe K;Reich K;Spuls P;Griffiths CE;Nast A;Franke J;Antoniou C;Arenberger P;Balieva F;Bylaite M;Correia O;Daudén E;Gisondi P;Iversen L;Kemény L;Lahfa M;Nijsten T;Rantanen T;Reich A;Rosenbach T;Segaert S;Smith C;Talme T;Volc-Platzer B;Yawalkar N
通讯作者：
Yawalkar N
微生物组和代谢组分析揭示系统性红斑狼疮脂质代谢的破坏
影响因子：
7.3
作者：
He, Jingquan;Chan, Tianlong;Dai, Yong
通讯作者：
Dai, Yong
肠道微生物组发酵决定运动预防糖尿病的功效
影响因子：
29
作者：
Liu, Yan;Wang, Yao;Xu, Aimin
通讯作者：
Xu, Aimin