The role of orexin-1 receptors in physiologic responses evoked by microinjection of PgE2 or muscimol into the medial preoptic area.
The role of orexin-1 receptors in physiologic responses evoked by microinjection of PgE2 or muscimol into the medial preoptic area.
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DOI：
10.1016/j.neulet.2011.05.006
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发表时间：
2011-07-08
影响因子：
2.5
通讯作者：
DiMicco JA
中科院分区：
文献类型：
--
作者：
Rusyniak DE;Zaretsky DV;Zaretskaia MV;DiMicco JA
长期以来，人们认为下丘脑的内侧视前区（mPOA）在发热产生和体温调节方面都发挥着重要作用。将前列腺素E2（PgE2）或γ-氨基丁酸A（GABAA）受体激动剂蝇蕈醇微量注射到mPOA中，会使体温、心率和血压出现类似的升高。然而，微量注射这些化合物会引发不同的行为反应，蝇蕈醇会增加活动量，而PgE2对活动量则没有影响。本研究旨在确定食欲素1型受体在介导这些不同反应中所起的作用。全身注射食欲素1型受体拮抗剂SB - 334867可降低蝇蕈醇微量注射所引起的体温和心血管反应，但对PgE2所引起的这两种反应均无影响。SB - 334867并未显著降低蝇蕈醇微量注射到mPOA所引发的活动量。这些数据表明，存在两条参与升高体温、心率和血压的中枢神经系统回路：一条是由蝇蕈醇激活的回路，涉及食欲素神经元；另一条则是由PgE2激活的、独立于食欲素的不同回路。
The medial preoptic area (mPOA) of the hypothalamus has long been thought to play an important role in both fever production and thermoregulation. Microinjections of prostaglandin E2 (PgE2) or the GABAA agonist muscimol into the mPOA cause similar increases in body temperature, heart rate, and blood pressure. Microinjections of these compounds however evoke different behavioral responses with muscimol increasing and PgE2 having no effect on locomotion. The purpose of this study was to determine the role of orexin-1 receptors in mediating these dissimilar responses. Systemic injections of the orexin-1 receptor antagonist SB-334867 reduced temperature and cardiovascular responses produced by microinjections of muscimol, but had no effect on either response produced by PgE2. SB-334867 did not significantly decrease locomotion evoked by microinjections of muscimol into the mPOA. These data suggest that there are two central nervous system circuits involved in increasing body temperature, heart rate and blood pressure: one circuit activated by muscimol, involving orexin neurons, and a separate orexin-independent circuit activated by PgE2.
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