The imaging quantification of multiple organs by dynamic (18)F-FDG PET/CT in discharged COVID-19 patients: A prospective pilot study.
The imaging quantification of multiple organs by dynamic (18)F-FDG PET/CT in discharged COVID-19 patients: A prospective pilot study.
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通过动态 18F-FDG PET/CT 对出院的 COVID-19 患者进行多器官成像定量：一项前瞻性试点研究
DOI：
10.7150/ijms.73801
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发表时间：
2022
影响因子：
3.6
通讯作者：
Jin H
中科院分区：
文献类型：
--
作者：
Yao J;Liu J;Bi L;Huang Y;Wang L;Zhang F;Wang Y;Jin H
目的：应用18F-FDG PET动态建模方法对COVID-19出院恢复期患者进行早期异常病灶识别。方法：前瞻性纳入7例出院COVID-19患者（COVID-19组）、12例健康志愿者（对照组1）和8例肺功能正常的癌症患者（对照组2）。对照组1只完成静态18F-FDG PET/CT；COVID-19组和对照组2完成60分钟动态18F-FDG PET/CT。在COVID-19组和对照组2中，动态扫描最后一帧（55-60分钟）FDG的摄取用于静态分析。在进行扫描之前，COVID-19患者提供了SARS-CoV-2实时逆转录聚合酶链反应（rRT-PCR）阴性，肺功能检查正常，实验室检查正常。根据常规静态数据进行器官-肝脏标准摄取比（OLR，即suvmaxevaluation脏器/ SUVmaxliver），并基于动态建模进行Patlak分析计算18F-FDG净摄取速率常数（Ki）。结果：与对照组相比，出院后2 ~ 3个月的COVID-19患者多脏器（包括肺、骨髓、淋巴结、心肌和肝脏）Ki值仍保持明显升高，但所有出院患者常规OLR测量结果均正常。以肺部图像为例，SUVmax图像在COVID-19组与对照组之间的差异难以区分。相比之下，在Ki图像中观察到COVID-19组肺部高18F-FDG信号。结论：18F-FDG PET/CT动态成像定量Ki可能有助于识别COVID-19幸存者的残留病变。试验注册：该试验已在ClinicalTrials.gov注册，注册号为NCT04519255 （irb批准号为K52-1）。
Purpose: To early identify abnormal lesions by applying the 18F-FDG PET dynamic modeling approach for discharged patients recovering from COVID-19. Methods: Seven discharged COVID-19 patients (COVID-19 group), twelve healthy volunteers (control group 1), and eight cancer patients with normal pulmonary function (control group 2) were prospectively enrolled. Control group 1 completed static 18F-FDG PET/CT only; COVID-19 group and control group 2 completed 60-min dynamic 18F-FDG PET/CT. Among COVID-19 group and control group 2, the uptake of FDG on the last frame (at 55-60 min) of dynamic scans was used for static analysis. Prior to performing scans, COVID-19 patients provided negative real-time Reverse Transcription-Polymerase Chain Reaction (rRT-PCR) of SARS-CoV-2, normal lung functions test, and normal laboratory test. Organ-to-liver standard uptake ratio (OLR, i.e. SUVmaxevaluated organ/ SUVmaxliver) from conventional static data and Patlak analysis based on the dynamic modeling to calculate the 18F-FDG net uptake rate constant (Ki) were performed. Results: Compared to the control groups, COVID-19 patients at two to three months after discharge still maintained significantly higher Ki values in multiple organs (including lung, bone marrow, lymph nodes, myocardium and liver), although results for regular OLR measurements were normal for all discharged COVID-19 patients. Taking the image of lung as an example, the differences of SUVmax images between COVID-19 group and control group were hard to distinguish. In contrast, a high 18F-FDG signal of the lung among the COVID-19 group was observed for Ki images. Conclusion: The Ki from 18F-FDG PET/CT dynamic imaging quantification might contribute to identifying residual lesions for COVID-19 survivors. Trial registration: The trial is registered with ClinicalTrials.gov, number NCT04519255 (IRB-approved number, K52-1).
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DOI：
10.1016/j.cmi.2020.09.023
发表时间：
2021-01
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Xiong Q;Xu M;Li J;Liu Y;Zhang J;Xu Y;Dong W
通讯作者：
Dong W
DOI：
10.15557/pimr.2020.0003
发表时间：
2020-01-01
影响因子：
3.6
作者：
通讯作者：
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95例SARS-CoV-2胃肠道症状
影响因子：
24.5
作者：
Lin, Lu;Jiang, Xiayang;Shan, Hong
通讯作者：
Shan, Hong
影响因子：
3.2
作者：
Chefer S;Thomasson D;Seidel J;Reba RC;Bohannon JK;Lackemeyer MG;Bartos C;Sayre PJ;Bollinger L;Hensley LE;Jahrling PB;Johnson RF
通讯作者：
Johnson RF
DOI：
10.1164/rccm.200904-0501oc
发表时间：
2009-09-15
影响因子：
24.7
作者：
Chen, Delphine L.;Bedient, Timothy J.;Walter, Michael J.
通讯作者：
Walter, Michael J.