Genes involved in copper resistance influence survival of Pseudomonas aeruginosa on copper surfaces.

Genes involved in copper resistance influence survival of Pseudomonas aeruginosa on copper surfaces.
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DOI:
10.1111/j.1365-2672.2009.04148.x
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发表时间:
2009-05
影响因子:
4
通讯作者:
Rensing C
Rensing C
中科院分区:
生物学3区
文献类型:
--
作者:
Elguindi J;Wagner J;Rensing C

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To evaluate the killing of Pseudomonas aeruginosa PAO1 on copper cast alloys and the influence of genes on survival on copper containing medium and surfaces. Different strains of P. aeruginosa were inoculated on copper containing medium or different copper cast alloys and the survival rate determined. The survival rates were compared to rates on copper-free medium and stainless steel as control. In addition, the effect of temperature on survival was examined. Copper cast alloys had previously shown to be bactericidal to various bacteria but the mechanism of copper-mediated killing is still not known. In this report we demonstrate that P. aeruginosa PAO1 is rapidly killed on different copper cast alloys and that genes involved in conferring copper resistance in copper-containing medium also influenced survival on copper cast alloys. We also show that the rate of killing is influenced by temperature.
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