The open versus blind weight conundrum: A multisite randomized controlled trial across multiple levels of patient care for anorexia nervosa.

The open versus blind weight conundrum: A multisite randomized controlled trial across multiple levels of patient care for anorexia nervosa.
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DOI:
10.1002/eat.23397
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发表时间:
2020-12
期刊:
The International journal of eating disorders
影响因子:
--
通讯作者:
Le Grange D
Le Grange D
中科院分区:
其他
文献类型:
--
作者:
Murray SB;Levinson CA;Farrell NR;Nagata JM;Compte EJ;Le Grange D

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神经性厌食症(AN)是一种以对体重增加的极度恐惧为特征的疾病,导致体重显著减轻,以及干扰体重正常化的行为症状。因此,体重增加仍然是治疗的近端目标,患者体重是治疗的关键组成部分。然而,在临床实践中如何进行患者称重存在不同的方法。本研究的目的是调查开放称重(与患者共享体重数据)与盲测(不与患者共享体重数据)对称重前后的痛苦和AN症状严重程度的影响。216例AN和非典型AN患者将在手动经验支持治疗的背景下,随机接受4周的住院、强化门诊和门诊治疗环境中的开放或盲态称重实践。开放或盲态称重4周后,所有患者将入组开放称重实践。关注的主要结局将是第5周时患者报告的体重困扰和第5周时的进食障碍症状严重程度。次要结果将评估体重预测误差,不确定性的耐受性和对食物的恐惧。没有最佳实践指南存在,以确定最佳做法周围称重患者与AN。这项多中心随机对照试验将提供关于开放与盲态称重实践对体重相关性痛苦和AN症状严重程度的影响的第一个已知数据。
Anorexia nervosa (AN) is a disorder characterized by a profound fear of weight gain, resulting in significant weight loss, as well as behavioral symptoms that interfere with weight normalization. In concert, weight gain remains a proximal goal of treatment, and patient weighing is a critical component of treatment. However, divergent approaches exist in how patient weighing is undertaken in clinical practice. The aim of this study is to investigate the impact of a brief course of open weighing (sharing weight data with patients) versus blind weighing (not sharing weight data with patients) on distress around being weighed and AN symptom severity. 216 patients with AN and atypical AN will be randomized to receive 4 weeks of open or blind weighing practices across residential, intensive outpatient, and outpatient treatment settings, within the context of manualized empirically supported treatment. Following 4 weeks of open or blind weighing, all patients will be enrolled into open weighing practices. Primary outcomes of interest will be patient-reported distress around being weighed at week 5 and eating disorder symptom severity at week 5. Secondary outcomes will assess weight prediction error, intolerance of uncertainty, and the fear of food. No best practice guidelines exist in determining optimal practices around weighing patients with AN. This multisite randomized controlled trial will provide the first known data on the impact of open versus blind weighing practices upon weight-related distress and AN symptom severity.
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