One year prospective survey of Candida bloodstream infections in Scotland.
One year prospective survey of Candida bloodstream infections in Scotland.
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DOI：
10.1099/jmm.0.47239-0
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发表时间：
2007-08
影响因子：
3
通讯作者：
Jones BL
中科院分区：
文献类型：
--
作者：
Odds FC;Hanson MF;Davidson AD;Jacobsen MD;Wright P;Whyte JA;Gow NAR;Jones BL
在英国苏格兰进行的一项为期12个月的念珠菌血症调查中，每个苏格兰医院实验室提交了所有酵母菌的血液分离株，用于鉴定、菌株分型和敏感性测试，从242名患者中提供了300株分离株，产生了每年每10万人4.8例和每10万急性住院日5.9例的发病率数据；27.9%的病例发生在重症监护病房。超过一半的念珠菌血症患者有潜在的腹部疾病，78%的患者有留置静脉导管，62%的患者在念珠菌血症发生前2周内发生过细菌感染，37%的患者接受过剖腹手术。白色念珠菌占50%，其次为光秃念珠菌（21%）和假丝酵母菌（12%）。7例念珠菌血症由都柏林念珠菌引起，其发生率高于卢西塔念珠菌和热带念珠菌（各6例）。其中，55%的菌株对氟康唑的敏感性降低，而其他菌株对氟康唑的抗性极低。多位点序列分型显示，高相似性的分离株来自全国不同的医院，许多不同类型的分离株来自提交分离株最多的医院，表明没有医院特有的地方性菌株的趋势。个别患者的白色念珠菌和面毛念珠菌的多个分离株均为同一菌株类型，每个物种均有单一例外。相对于其他基于人群的欧洲研究，念珠菌血症在苏格兰的高流行率，以及苏格兰glabrata分离株氟康唑敏感性的高水平降低，值得在未来继续监测侵袭性念珠菌感染。
A 12 month survey of candidaemia in Scotland, UK, in which every Scottish hospital laboratory submitted all blood isolates of yeasts for identification, strain typing and susceptibility testing, provided 300 isolates from 242 patients, generating incidence data of 4.8 cases per 100 000 population per year and 5.9 cases per 100 000 acute occupied bed days; 27.9 % of cases occurred in intensive care units. More than half the patients with candidaemia had an underlying disease involving the abdomen, 78 % had an indwelling intravenous catheter, 62 % had suffered a bacterial infection within the 2 weeks prior to candidaemia and 37 % had undergone a laparotomy. Candida albicans was the infecting species in 50 % of cases, followed by Candida glabrata (21 %) and Candida parapsilosis (12 %). Seven cases of candidaemia were caused by Candida dubliniensis, which was more prevalent even than Candida lusitaniae and Candida tropicalis (six cases each). Among C. glabrata isolates, 55 % showed reduced susceptibility to fluconazole, but azole resistance among other species was extremely low. Multilocus sequence typing showed isolates with high similarity came from different hospitals across the country, and many different types came from the hospitals that submitted the most isolates, indicating no tendency towards hospital-specific endemic strains. Multiple isolates of C. albicans and C. glabrata from individual patients were of the same strain type with single exceptions for each species. The high prevalence of candidaemia in Scotland, relative to other population-based European studies, and the high level of reduced fluconazole susceptibility of Scottish C. glabrata isolates warrant continued future surveillance of invasive Candida infections.
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影响因子：
11.8
作者：
Marchetti, O;Bille, J;Pittet, D
通讯作者：
Pittet, D
影响因子：
9.4
作者：
Asmundsdóttir, LR;Erlendsdóttir, H;Gottfredsson, M
通讯作者：
Gottfredsson, M
影响因子：
14.2
作者：
Cuenca-Estrella, M;Moore, CB;Rodríguez-Tudela, JL
通讯作者：
Rodríguez-Tudela, JL
影响因子：
158.5
作者：
COHEN, R;ROTH, FJ;KALSER, MH
通讯作者：
KALSER, MH
影响因子：
3.2
作者：
Feil, EJ;Li, BC;Spratt, BG
通讯作者：
Spratt, BG