Metabolic reprogramming and apoptosis sensitivity: Defining the contours of a T cell response.
Metabolic reprogramming and apoptosis sensitivity: Defining the contours of a T cell response.
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DOI：
10.1016/j.canlet.2017.08.033
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发表时间：
2017-11-01
期刊：
影响因子：
9.7
通讯作者：
Snow AL
中科院分区：
文献类型：
--
作者：
Voss K;Larsen SE;Snow AL
有效的适应性免疫应答取决于T细胞响应于抗原的快速克隆扩增。这些T细胞对程序性细胞死亡（即细胞凋亡）的敏感性在各个阶段被仔细校准，以确保在不对宿主组织造成意外损伤的情况下解决的稳健但可测量的反应。为了满足与剧烈增殖、获得效应子功能和记忆形成相关的生物能量需求，T细胞在这种反应的每个阶段也经历其代谢的动态变化。在这篇综述中，我们专注于相对较新的研究，阐明代谢程序和T细胞凋亡敏感性之间的密切联系。然后，我们研究了这些连接最终如何影响T细胞的生存和功能的肿瘤微环境的代谢负担环境。
An effective adaptive immune response hinges on the rapid clonal expansion of T cells in response to antigen. The sensitivity of these T cells to programmed cell death (i.e. apoptosis) is carefully calibrated at various stages to ensure a robust yet measured reaction that resolves without inflicting unintended damage to host tissues. To meet bioenergetic demands associated with vigorous proliferation, acquisition of effector functions, and memory formation, T cells also undergo dynamic changes in their metabolism at every stage of this response. In this review, we focus on relatively recent studies that illuminate intimate links between metabolic programs and apoptosis sensitivity in T cells. We then examine how these connections ultimately influence T cell survival and function within the metabolically taxing environs of the tumor microenvironment.
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影响因子：
16
作者：
Andersen, Joshua L.;Kornbluth, Sally
通讯作者：
Kornbluth, Sally
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