Arterial spin labeling MRI for assessment of perfusion in native and transplanted kidneys.
Arterial spin labeling MRI for assessment of perfusion in native and transplanted kidneys.
复制标题
动脉自旋标记MRI用于评估天然和移植肾脏的灌注。
DOI：
10.1016/j.mri.2010.07.018
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发表时间：
2011-01
影响因子：
2.5
通讯作者：
Fain, Sean B.
中科院分区：
文献类型：
--
作者：
Artz, Nathan S.;Sadowski, Elizabeth A.;Wentland, Andrew L.;Grist, Thomas M.;Seo, Songwon;Djamali, Arjang;Fain, Sean B.
应用磁共振 (MR) 动脉自旋标记 (ASL) 技术来评估自体肾脏和移植肾脏的肾脏灌注。本研究符合健康保险流通与责任法案 (HIPAA) 并得到机构审查委员会的批准。所有受试者均获得知情同意。总共 25 名受试者以 1.5 T 进行肾灌注检查：10 名受试者为自体肾脏，15 名受试者为移植肾。对所有受试者进行呼吸触发，并在 5 名移植受试者的自由呼吸条件下进行流量敏感交替反转恢复 (FAIR) ASL 序列。使用单室模型获取并处理了 32 个对照/标签对。对高于和低于估计肾小球滤过率 (eGFR) 阈值 60 ml/min/1.73m2 的自体肾和移植肾的灌注进行比较，并确定与 eGFR 的相关性。在许多移植的肾脏中，冠状面上的主要供血血管需要与肾脏矢状方向的切片。在天然受试者和移植受试者中观察检查期间的肾运动，并通过配准进行校正。在天然受试者（r=0.85，p=0.002）和移植受试者（r=0.61，p=0.02）中，皮质灌注与 eGFR 相关。对于 eGFR≥60 ml/min/1.73m2 的受试者，自体肾表现出比移植肾更大的皮质 (p=0.01) 和髓质 (p=0.04) 灌注。对于 eGFR<60 ml/min/1.73m2 的受试者，与移植肾相比，自体肾表现出更大的髓质灌注 (p=0.04)。自由呼吸采集提供的肾灌注测量值略低于指导/触发技术，但没有观察到统计差异。总之，FAIR-ASL 能够测量自体肾脏和移植肾脏受试者的肾灌注，可能为监测肾功能提供临床上可行的技术。
To apply a magnetic resonance (MR) arterial spin labeling (ASL) technique to evaluate kidney perfusion in native and transplanted kidneys. This study was compliant with the Health Insurance Portability and Accountability Act (HIPAA) and approved by the institutional review board. Informed consent was obtained from all subjects. Renal perfusion exams were performed at 1.5 T in a total of 25 subjects: 10 with native and 15 with transplanted kidneys. A flow-sensitive alternating inversion recovery (FAIR) ASL sequence was performed with respiratory triggering in all subjects and under free-breathing conditions in five transplant subjects. Thirty-two control/tag pairs were acquired and processed using a single-compartment model. Perfusion in native and transplanted kidneys was compared above and below an estimated glomerular filtration rate (eGFR) threshold of 60 ml/min/1.73m2 and correlations with eGFR were determined. In many of the transplanted kidneys, major feeding vessels in the coronal plane required a slice orientation sagittal to the kidney. Renal motion during the examination was observed in native and transplant subjects and was corrected with registration. Cortical perfusion correlated with eGFR in native (r=0.85, p=0.002) and transplant subjects (r=0.61, p=0.02). For subjects with eGFR≥60 ml/min/1.73m2, native kidneys demonstrated greater cortical (p=0.01) and medullary (p=0.04) perfusion than transplanted kidneys. For subjects with eGFR<60 ml/min/1.73m2, native kidneys demonstrated greater medullary perfusion (p=0.04) compared to transplanted kidneys. Free-breathing acquisitions provided renal perfusion measurements that were slightly lower compared to the coached/triggered technique, although no statistical differences were observed. In conclusion, FAIR-ASL was able to measure renal perfusion in subjects with native and transplanted kidneys, potentially providing a clinically viable technique for monitoring kidney function.
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影响因子：
1.8
作者：
Mervaala, E;Lassila, M;Karppanen, H
通讯作者：
Karppanen, H
影响因子：
1.1
作者：
Irshad, Abid;Ackerman, Susan J.;Anis, Munazza
通讯作者：
Anis, Munazza
DOI：
10.1152/ajpregu.00766.2002
发表时间：
2003-09-01
影响因子：
2.8
作者：
Just, A;Arendshorst, WJ
通讯作者：
Arendshorst, WJ
DOI：
10.1055/s-2005-858761
发表时间：
2005-12-01
影响因子：
1.8
作者：
Boss, A;Martirosian, P;Schick, F
通讯作者：
Schick, F
影响因子：
19.7
作者：
Fenchel, M;Martirosian, P;Schick, F
通讯作者：
Schick, F