Serum brain injury biomarkers are gestationally and post-natally regulated in non-brain injured neonates.
Serum brain injury biomarkers are gestationally and post-natally regulated in non-brain injured neonates.
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DOI：
10.1038/s41390-021-01906-8
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发表时间：
2023-06
影响因子：
3.6
通讯作者：
Everett, Allen D.
中科院分区：
文献类型：
--
作者：
Brooks, Sandra;Friedes, Barbara D.;Northington, Frances;Graham, Ernest;Tekes, Aylin;Burton, Vera J.;Gerner, Gwendolyn;Zhu, Jie;Chavez-Valdez, Raul;Vaidya, Dhananjay;Everett, Allen D.
确定胎龄（GA）和出生日（DOL）与GA 23-41周之间出生的非脑损伤新生儿中6种脑损伤相关生物标志物的循环血清浓度的相关性。在一项多中心前瞻性观察性队列研究中，在前7个DOL每天测量血清CNS损伤、炎症和营养蛋白浓度。分析了来自745名入组者的3232份血清样本，中位GA 32.3周。BDNF和IL-8在妊娠各周分别增加3.7%和8.9%。VEGF、IL-6、IL-10与GA无相关性。VEGF和IL-8分别升高10.8%和18.9%。IL-6每DOL降低15.8%。对于DOL 0-3，IL-10每个DOL降低81.4%。BDNF与DOL无明显相关性。GFAP阳性率为49.67%，NRGN阳性率为33.15%。在36周的GA后，每周可检测到GFAP和NRGN的几率分别增加53%和11%。每个DOL，可检测到GFAP和NRGN的几率分别下降15%和8%。BDNF和IL-8血清浓度随GA而变化。VEGF和白细胞介素浓度在生命的第一周是动态的，这表明循环水平应根据GA和DOL进行调整，以进行临床相关的脑损伤评估。
To determine the association of gestational age (GA) and day of life (DOL) with the circulating serum concentration of six brain injury-associated biomarkers in non-brain injured neonates born between 23–41 weeks’ GA. In a multicenter prospective observational cohort study, serum CNS-insult, inflammatory and trophic proteins concentrations were measured daily in the first 7 DOL. 3232 serum samples were analyzed from 745 enrollees, median GA 32.3 weeks. BDNF increased 3.7% and IL-8 increased 8.9% each week of gestation. VEGF, IL-6, and IL-10 showed no relationship with GA. VEGF increased 10.8% and IL-8 18.9%, each DOL. IL-6 decreased by 15.8% each DOL. IL-10 decreased by 81.4% each DOL for DOL 0–3. BDNF did not change with DOL. Only 49.67% of samples had detectable GFAP and 33.15% had detectable NRGN. The odds of having detectable GFAP and NRGN increased by 53% and 11%, respectively, each week after 36 weeks’ GA. The odds of having detectable GFAP and NRGN decreased by 15% and 8%, respectively, each DOL. BDNF and IL-8 serum concentrations vary with GA. VEGF and interleukin concentrations are dynamic in the first week of life, suggesting circulating levels should be adjusted for GA and DOL for clinically relevant assessment of brain injury.
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影响因子：
3.7
作者：
Blennow K
通讯作者：
Blennow K
影响因子：
1
作者：
Easley RB;Marino BS;Jennings J;Cassedy AE;Kibler KK;Brady KM;Andropoulos DB;Brunetti M;Hogue CW;Heitmiller ES;Lee JK;Spaeth J;Everett AD
通讯作者：
Everett AD
DOI：
10.1017/s1461145710000738
发表时间：
2011-04-01
影响因子：
4.8
作者：
Klein, Anders B.;Williamson, Rebecca;Aznar, Susana
通讯作者：
Aznar, Susana
影响因子：
1.9
作者：
Gerner, Gwendolyn J.;Newman, Eric, I;Poretti, Andrea
通讯作者：
Poretti, Andrea
影响因子：
6.8
作者：
Grad, S;Ertel, W;Maly, FE
通讯作者：
Maly, FE