Mapping the pathways of information processing from sensation to action in four distinct sensorimotor tasks.
Mapping the pathways of information processing from sensation to action in four distinct sensorimotor tasks.
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DOI：
10.1002/hbm.20837
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发表时间：
2009-12
影响因子：
4.8
通讯作者：
Marois R
中科院分区：
文献类型：
--
作者：
Ivanoff J;Branning P;Marois R
两个既不共享感觉也不共享运动模式的感觉运动任务在同时执行时可能会相互干扰。造成这种干扰的一个可能原因是，这两项任务占用了大脑的共同区域，从而造成了信息处理的瓶颈。这一假设预测，即使是单独执行任务，这些“瓶颈”区域也会被每个任务激活。为了验证这一预测，我们试图用功能磁共振成像（fMRI）识别通常被感觉运动任务激活的大脑区域，这些区域既不共享感觉输入，也不共享运动输出。一组受试者在分别执行听觉-声音（AVo）任务和视觉-手动（ViM）任务时进行扫描，而另一组受试者执行反向感觉运动映射任务（AM和ViVo）。结果显示，在特定的感觉和运动皮层区域，每种感觉和运动模式都有强烈的激活偏好。相比之下，在所有四种感觉运动任务中，外侧前额叶皮层（pLPFC）的后部、前脑岛，以及不太一致的前扣带、前辅助运动区和辅助运动区以及皮质下区域都被普遍激活。这些结果在阻塞和事件相关的fMRI设计中都观察到了，在3d组平均和2d个体受试者分析中都观察到了，并且在整个扫描过程中在个体中得到了重复。这些发现不仅表明这些大脑区域可能在感觉运动任务中起着共同的模态功能，而且还指出这些区域——特别是pLPFC和前脑岛——是人脑中信息处理中枢的候选神经基质。
Two sensorimotor tasks that share neither sensory nor motor modality can interfere with one another when they are performed simultaneously. A possible cause for this interference is the recruitment of common brain regions by these two tasks, thereby creating a bottleneck of information processing. This hypothesis predicts that such ‘bottleneck’ regions would be activated by each task even when they are performed separately. To test this prediction, we sought to identify, with fMRI, brain regions commonly activated by sensorimotor tasks that share neither sensory input nor motor output. One group of subjects was scanned while they performed in separate runs an auditory-vocal (AVo) task and a visuo-manual (ViM) task, while a second group of subjects performed the reversed sensorimotor mapping tasks (AM and ViVo). The results revealed strong activation preferences in specific sensory and motor cortical areas for each sensory and motor modality. By contrast, the posterior portion of the lateral prefrontal cortex (pLPFC), anterior insula, and, less consistently, the anterior cingulate, pre-supplementary and supplementary motor areas, and subcortical areas were commonly activated across all four sensorimotor tasks. These results were observed in both blocked and event-related fMRI designs, in both 3D-group averaged and 2D-individual subject analyses, and were replicated within individuals across scanning sessions. These findings not only suggest that these brain regions may serve a common amodal function in sensorimotor tasks, they also point to these regions – particularly the pLPFC and anterior insula – as candidate neural substrates underlying a central hub of information processing in the human brain.
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影响因子：
56.9
作者：
Calvert, GA;Bullmore, ET;David, AS
通讯作者：
David, AS
DOI：
10.1073/pnas.050583797
发表时间：
2000-03-28
影响因子：
11.1
作者：
Bunge, SA;Klingberg, T;Gabrieli, JDE
通讯作者：
Gabrieli, JDE
影响因子：
5.7
作者：
Desmond, JE;Gabrieli, JDE;Glover, GH
通讯作者：
Glover, GH
影响因子：
25
作者：
Bushara, KO;Hanakawa, T;Hallett, M
通讯作者：
Hallett, M
影响因子：
3.7
作者：
Brass, M;von Cramon, DY
通讯作者：
von Cramon, DY