Expression of rat target of the antiproliferative antibody (TAPA) in the developing brain
Expression of rat target of the antiproliferative antibody (TAPA) in the developing brain
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大鼠抗增殖抗体（TAPA）靶点在发育中大脑中的表达
DOI：
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
E. Geisert
中科院分区：
文献类型：
--
作者：
C. D. Sullivan;E. Geisert
The present study defines the expression pattern of TAPA (target of the antiproliferative antibody, also known as CD81) in the developing rat brain. TAPA is a member of the tetramembrane spanning family of proteins, and like other members of this family it appears to be associated with the stabilization of cellular contacts (Geisert et al. [1996] J. Neurosci. 16:5478–5487). On immunoblots of the brain, TAPA is present in higher levels than any other tissue examined: muscle, tendon, peripheral nerve, cartilage, liver, kidney, skin, and testicle. Immunohistochemical methods were used to define the distribution of TAPA in the brain. This protein is expressed by ependyma, choroid plexus, astrocytes, and oligodendrocytes. TAPA is dramatically upregulated during early postnatal development, at the time of glial birth and maturation. At embryonic day 18, the levels of TAPA are low, with most of the immunoreaction product being associated with the ependyma, choroid plexus, and the glia limitans. As development continues, the amount of TAPA expressed in the brain increases, and at postnatal day 14 the levels approach those of the adult. This increase in the levels of TAPA at postnatal day 14 is due to upregulation in the gray matter and white matter. Thus, TAPA is found in all glial cells, and the level of this protein correlates with their maturation. J. Comp. Neurol. 396:366–380, 1998. © 1998 Wiley‐Liss, Inc.
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通过神经上皮末足上预先形成的粘附通路对体内视轴突进行引导。
影响因子：
2.7
作者：
Silver,J;Rutishauser,U
通讯作者：
Rutishauser,U
抗人血小板 p24/CD9 单克隆抗体介导的人血小板活化。
DOI：
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发表时间：
1990
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Jennings,LK;Fox,CF;Kouns,WC;McKay,CP;Ballou,LR;Schultz,HE
通讯作者：
Schultz,HE
抗 TAPA-1 抗体可诱导蛋白质酪氨酸磷酸化，而这种磷酸化可通过增加细胞内硫醇水平来阻止。
DOI：
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发表时间：
1993
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Schick,MR;Nguyen,VQ;Levy,S
通讯作者：
Levy,S
影响因子：
56.9
作者：
DONG, JT;LAMB, PW;BARRETT, JC
通讯作者：
BARRETT, JC