Treadmill exercise and resistance training in patients with peripheral arterial disease with and without intermittent claudication: a randomized controlled trial.
Treadmill exercise and resistance training in patients with peripheral arterial disease with and without intermittent claudication: a randomized controlled trial.
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DOI：
10.1001/jama.2008.962
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发表时间：
2009-01-14
影响因子：
120.7
通讯作者：
Criqui, Michael H.
中科院分区：
文献类型：
--
作者：
McDermott, Mary M.;Ades, Philip;Guralnik, Jack M.;Dyer, Alan;Ferrucci, Luigi;Liu, Kiang;Nelson, Miriam;Lloyd-Jones, Donald;Van Horn, Linda;Garside, Daniel;Kibbe, Melina;Domanchuk, Kathryn;Stein, James H.;Liao, Yihua;Tao, Huimin;Green, David;Pearce, William H.;Schneider, Joseph R.;McPherson, David;Laing, Susan T.;McCarthy, Walter J.;Shroff, Adhir;Criqui, Michael H.
力量训练在外周动脉疾病（PAD）中的作用尚不清楚。没有间歇性跛行（IC）的PAD患者在监督下进行跑步机运动的益处尚未确定。为了确定与对照组相比，有或无IC的PAD患者在监督下的跑步机运动和下肢阻力训练是否分别改善了功能表现。在2004年4月1日至2008年8月19日进行了随机对照临床试验。156名PAD患者（踝肱指数≤0.95），其中81.4%没有IC。主要结果是6分钟步行表现和短体能表现电池（SPPB）。其他结果包括肱动脉血流介导的扩张（FMD）、跑步机行走表现、行走障碍问卷（WIQ）和短表36身体功能评分（sf - 36pf）。三个平行手臂：有监督的跑步机训练，有监督的下肢阻力训练，和一个对照组。与对照组相比，跑步机运动组增加了6分钟步行距离(+35.9米，95%可信区间（CI）， +15.3至+56.5；P <0.001)，而阻力训练组没有改善（+12.4米，95% CI,−8.42至+33.3；P=0.24）。两组运动均未改善SPPB。与对照组相比，跑步机运动改善了肱动脉FMD （+1.53%, 95% CI, +0.35 ~ +2.70， P=0.018）、跑步机时间（+3.44分钟，95% CI, +2.05 ~ +4.84， P<0.001）、WIQ距离评分P=0.015)和sf - 36pf评分（P=0.02）。与对照组相比，阻力训练改善了跑步机时间（+1.98分钟，95% CI, +0.56至+3.39；P=0.007）、WIQ距离评分（P=0.02）、WIQ爬楼梯评分（P=0.02）和sf - 36pf评分（P=0.04）。有监督的跑步机运动改善了有或没有经典IC症状的PAD参与者的6分钟步行距离、跑步机步行表现、肱动脉FMD和生活质量，但没有改善SPPB。阻力训练改善了PAD患者的跑步机行走性能、生活质量和爬楼梯能力。
The role of strength training in peripheral arterial disease (PAD) is unclear. Benefits of supervised treadmill exercise in PAD patients without intermittent claudication (IC) are not established. To determine whether supervised treadmill exercise and lower extremity resistance training, respectively, improve functional performance compared to a control group in PAD persons with and without IC. Randomized controlled clinical trial performed between 4/1/04 and 8/19/08. 156 people with PAD (ankle brachial index ≤ 0.95), including 81.4% without IC. Primary outcomes were six-minute walk performance and the short physical performance battery (SPPB). Additional outcomes were brachial artery flow-mediated dilation (FMD), treadmill walking performance, the Walking Impairment Questionnaire (WIQ), and the Short-Form 36 Physical Functioning score (SF-36 PF). Three parallel arms: supervised treadmill exercise, supervised lower extremity resistance training, and a control group. Compared to control, the treadmill exercise group increased six-minute walk distance (+35.9 meters, 95% confidence interval (CI), +15.3 to +56.5; P <0.001), while the resistance trained group did not improve (+12.4 meters, 95% CI, −8.42 to +33.3; P=0.24). Neither exercise group improved the SPPB. Compared to control, treadmill exercise improved brachial artery FMD (+1.53%, 95% CI, +0.35 to +2.70, P=0.018), time on treadmill (+3.44 minutes, 95% CI, +2.05 to +4.84; P<0.001), the WIQ distance score P=0.015), and the SF-36 PF score (P=0.02). Compared to control, resistance training improved time on treadmill (+1.98 minutes, 95% CI, +0.56 to +3.39; P=0.007), the WIQ distance score (P=0.02), the WIQ stair climbing score (P=0.02), and the SF-36 PF score (P=0.04). Supervised treadmill exercise improved six-minute walk distance, treadmill walking performance, brachial artery FMD, and quality of life, but not the SPPB, in PAD participants with and without classic IC symptoms. Resistance training improved treadmill walking performance, quality of life, and stair climbing ability in patients with PAD.
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影响因子：
120.7
作者：
Fowkes, F. G. R.;Murray, G. D.;Butcher, I.;Heald, C. L.;Lee, R. J.;Chambless, L. E.;Folsom, A. R.;Hirsch, A. T.;Dramaix, M.;deBacker, G.;Wautrecht, J-C.;Kornitzer, M.;Newman, A. B.;Cushman, M.;Sutton-Tyrrell, K.;Lee, A. J.;Price, J. F.;d'Agostino, R. B.;Murabito, J. M.;Norman, P. E.;Jamrozik, K.;Curb, J. D.;Masaki, K. H.;Rodriquez, B. L.;Dekker, J. M.;Bouter, L. M.;Heine, R. J.;Nijpels, G.;Stehouwer, C. D. A.;Ferrucci, L.;McDermott, M. M.;Stoffers, H. E.;Hooi, J. D.;Knottnerus, J. A.;Ogren, M.;Hedblad, B.;Witteman, J. C.;Breteler, M. M. B.;Hunink, M. G. M.;Hofman, A.;Criqui, M. H.;Langer, R. D.;Fronek, A.;Hiatt, W. R.;Hamman, R.;Resnick, H. E.;Guralnik, J.;McDermott, M. M.
通讯作者：
McDermott, M. M.
DOI：
10.1111/j.1532-5415.2006.00700.x
发表时间：
2006-05-01
影响因子：
6.3
作者：
Curb, J. David;Ceria-Ulep, Clementina D.;Chen, Randi
通讯作者：
Chen, Randi
影响因子：
37.8
作者：
McDermott, MM;Fried, L;Guralnik, JM
通讯作者：
Guralnik, JM
影响因子：
37.8
作者：
Garg, Parveen K.;Tian, Lu;McDermott, Mary M.
通讯作者：
McDermott, Mary M.
影响因子：
39.2
作者：
McDermott, MM;Greenland, P;Clark, E
通讯作者：
Clark, E