Distinct neural mechanisms for remembering when an event occurred.

Distinct neural mechanisms for remembering when an event occurred.
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DOI:
10.1002/hipo.22571
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发表时间:
2016-05
期刊:
影响因子:
3.5
通讯作者:
Ranganath C
Ranganath C
中科院分区:
医学3区
文献类型:
--
作者:
Jenkins LJ;Ranganath C

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事件通常被记住是按照特定的顺序发生的,但几乎没有人知道大脑如何编码这种时间信息。通常认为时间信息是通过单一机制编码的,基于事件发生的时间上下文或从记忆痕迹本身的强度推断。通过分析活动模式的时间依赖性变化,我们发现,海马和前额叶皮层前部和内侧的上下文表征的独特性与准确的近因记忆。相比之下,无论准确性如何,嗅周和外侧前额叶皮质的整体激活都能预测物体是否会被判断为最近。这些结果表明,时间信息编码通过至少两个互补的神经机制。
Events are often remembered as having occurred in a specific order, but almost nothing is known about how the brain encodes this temporal information. It is commonly assumed that temporal information is encoded via a single mechanism, based either on the temporal context in which the event occurred or inferred from the strength of the memory trace itself. By analyzing time-dependent changes in activity patterns, we show that the distinctiveness of contextual representations in the hippocampus and anterior and medial prefrontal cortex was associated with accurate recency memory. In contrast, overall activation in the perirhinal and lateral prefrontal cortices predicted whether an object would be judged more recent, regardless of accuracy. These results demonstrate that temporal information is encoded through at least two complementary neural mechanisms.
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