Distinct neural mechanisms for remembering when an event occurred.
Distinct neural mechanisms for remembering when an event occurred.
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DOI:
10.1002/hipo.22571
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发表时间:
2016-05
期刊:
影响因子:
3.5
通讯作者:
Ranganath C
中科院分区:
文献类型:
--
作者:
Jenkins LJ;Ranganath C
Events are often remembered as having occurred in a specific order, but almost nothing is known about how the brain encodes this temporal information. It is commonly assumed that temporal information is encoded via a single mechanism, based either on the temporal context in which the event occurred or inferred from the strength of the memory trace itself. By analyzing time-dependent changes in activity patterns, we show that the distinctiveness of contextual representations in the hippocampus and anterior and medial prefrontal cortex was associated with accurate recency memory. In contrast, overall activation in the perirhinal and lateral prefrontal cortices predicted whether an object would be judged more recent, regardless of accuracy. These results demonstrate that temporal information is encoded through at least two complementary neural mechanisms.
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