Topographic Cortico-cerebellar Networks Revealed by Visual Attention and Working Memory.
Topographic Cortico-cerebellar Networks Revealed by Visual Attention and Working Memory.
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DOI：
10.1016/j.cub.2018.08.059
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发表时间：
2018-11-05
期刊：
影响因子：
--
通讯作者：
Somers DC
中科院分区：
文献类型：
--
作者：
Brissenden JA;Tobyne SM;Osher DE;Levin EJ;Halko MA;Somers DC
小脑的大部分似乎支持非运动功能，然而，以前的研究小脑参与认知只揭示了一个粗略的特异性程度。虽然在小脑内已经观察到了躯体位置图，但在支持非运动功能的皮质-小脑网络内类似的精确度以前还没有报道。在这里，我们发现，人类小脑小叶VIIb/VIIIa差异编码视觉空间认知的关键方面。在视觉工作记忆和注意力要求高的视觉感受野映射fMRI任务范式中观察到同侧视觉空间表征。此外，在小叶VIIb/VIIIa，我们观察到空间编码和视觉工作记忆处理之间的功能分离。视觉空间表征被发现在小叶VIIb/VIIIa的背内侧部分和负荷依赖的视觉工作记忆处理转移到腹外侧。在后顶叶皮层中发现了空间与负荷处理的类似功能梯度。这种大脑皮层组织的功能连接与小脑小叶VIIb/VIIIa的空间和负荷区域预测。总的来说，我们的研究结果表明，招聘的视觉空间注意功能在小脑小叶VIIb/VIIIa是高度特异性的。此外，这些功能的地形安排反映在额叶和顶叶皮层。这些发现激发了对广泛认知领域的皮质-小脑功能特化的更深入研究。Bossenden等人证明了小脑对视觉认知处理的精确贡献，并建立了两个支持视觉空间认知不同方面的皮质-小脑子网络的存在。这种地形的特异性表明，细颗粒的皮质-小脑回路在认知过程中发挥着重要作用。
Substantial portions of the cerebellum appear to support non-motor functions; however, previous investigations of cerebellar involvement in cognition have revealed only a coarse degree of specificity. Although somatotopic maps have been observed within cerebellum, similar precision within cortico-cerebellar networks supporting non-motor functions has not previously been reported. Here, we find that human cerebellar lobule VIIb/VIIIa differentially codes key aspects of visuospatial cognition. Ipsilateral visuospatial representations were observed during both a visual working memory and an attentionally demanding visual receptive field mapping fMRI task paradigm. Moreover, within lobule VIIb/VIIIa, we observed a functional dissociation between spatial coding and visual working memory processing. Visuospatial representations were found in the dorsomedial portion of lobule VIIb/VIIIa and load-dependent visual working memory processing was shifted ventrolaterally. A similar functional gradient for spatial vs. load processing was found in posterior parietal cortex. This cerebral cortical organization was well predicted by functional connectivity with spatial and load regions of cerebellar lobule VIIb/VIIIa. Collectively, our findings indicate that recruitment by visuospatial attentional functions within cerebellar lobule VIIb/VIIIa is highly specific. Furthermore, the topographic arrangement of these functions is mirrored in frontal and parietal cortex. These findings motivate a closer examination of cortico-cerebellar functional specialization across a broad range of cognitive domains. Brissenden et al. demonstrate precise cerebellar contributions to visual cognitive processing and establish the existence of two cortico-cerebellar subnetworks that support different aspects of visuospatial cognition. This topographic specificity suggests that fine-grained cortico-cerebellar loops play a prominent role in cognitive processing.
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影响因子：
5.3
作者：
Brissenden, James A.;Levin, Emily J.;Somers, David C.
通讯作者：
Somers, David C.
影响因子：
3.5
作者：
Baumann, Oliver;Borra, Ronald J.;Bower, James M.;Cullen, Kathleen E.;Habas, Christophe;Ivry, Richard B.;Leggio, Maria;Mattingley, Jason B.;Molinari, Marco;Moulton, Eric A.;Paulin, Michael G.;Pavlova, Marina A.;Schmahmann, Jeremy D.;Sokolov, Arseny A.
通讯作者：
Sokolov, Arseny A.
影响因子：
5.7
作者：
Diedrichsen, Joern;Balsters, Joshua H.;Ramnani, Narender
通讯作者：
Ramnani, Narender
影响因子：
56.9
作者：
Allen, G;Buxton, RB;Courchesne, E
通讯作者：
Courchesne, E
影响因子：
5.7
作者：
Fischl, Bruce
通讯作者：
Fischl, Bruce