Test-retest reproducibility of a rapid method to measure brain oxygen metabolism.
Test-retest reproducibility of a rapid method to measure brain oxygen metabolism.
复制标题
DOI：
10.1002/mrm.24295
复制
发表时间：
2013-03-01
影响因子：
3.3
通讯作者：
Lu, Hanzhang
中科院分区：
文献类型：
--
作者：
Liu, Peiying;Xu, Feng;Lu, Hanzhang
关键词：
脑氧代谢率(CMRO2)是组织活力和脑功能的重要指标，但临床扫描仪还不能常规测量这一参数。最近，有人提出了一种无创技术，通过使用T2松弛自旋标记(TRUST)MRI和脉搏血氧仪同时测量氧提取分数(OEF)和相位对比MRI测量脑血流量(CBF)来估计全球CMRO2。本研究试图为这项技术建立一个标准的获取程序，并评估其在健康受试者中的重测重复性。每个受试者在五次会议中接受检查，每一次会议包括两项测量。CMRO2的批内变异系数(CoV)为3.84±1.44%(N=7)，批间变异系数为6.59±1.56%，批间变异系数为8.80%。这些重复性值与文献中报道的150度正电子发射计算机断层扫描结果相当或略好。研究还发现，OEF和CBF倾向于在不同时段(p=0.002)和不同受试者(p=0.01)之间存在协变性，并且它们的CoVS大于CMRO2。简单和可靠的特点可能为这种全球性的CMRO2技术提供立即临床应用的巨大潜力。
Cerebral metabolic rate of oxygen (CMRO2) is an important index of tissue viability and brain function, but this parameter cannot yet be measured routinely on clinical scanners. Recently, a non-invasive technique was proposed which estimates global CMRO2 by concomitantly measuring Oxygen-Extraction-Fraction (OEF) using T2-Relaxation-Under-Spin-Tagging (TRUST) MRI and pulse oximetry, and Cerebral-Blood-Flow (CBF) using phase-contrast MRI. The present study sought to establish a standard acquisition procedure for this technique and to evaluate its test-retest reproducibility in healthy subjects. Each subject was examined in five sessions and each session included two measurements. Intra-session, inter-session, and inter-subject coefficients of variation (CoV) for CMRO2 were found to be 3.84±1.44% (N=7, mean ± standard deviation), 6.59 ± 1.56%, and 8.80% respectively. These reproducibility values were comparable or slightly superior to 15O PET results reported in the literature. It was also found that OEF and CBF tended to co-vary across sessions (p=0.002) and subjects (p=0.01), and their CoVs were greater than that of CMRO2. The simplicity and reliability features may afford this global CMRO2 technique great potential for immediate clinical applications.
登录
查看更多内容
影响因子：
6.3
作者：
Ge, Yulin;Zhang, Zhongwei;Grossman, Robert I.
通讯作者：
Grossman, Robert I.
DOI：
10.1073/pnas.83.4.1140
发表时间：
1986-02-01
影响因子：
11.1
作者：
FOX, PT;RAICHLE, ME
通讯作者：
RAICHLE, ME
影响因子：
6.7
作者：
EVANS, AJ;IWAI, F;PELC, NJ
通讯作者：
PELC, NJ
影响因子：
6.3
作者：
Chen, J. Jean;Pike, G. Bruce
通讯作者：
Pike, G. Bruce
影响因子：
3.3
作者：
He, Xiang;Yablonskiy, Dmitriy A.
通讯作者：
Yablonskiy, Dmitriy A.