Functions and clinical significance of mechanical tumor microenvironment: cancer cell sensing, mechanobiology and metastasis.
Functions and clinical significance of mechanical tumor microenvironment: cancer cell sensing, mechanobiology and metastasis.
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机械肿瘤微环境的功能和临床意义：癌细胞传感、机械生物学和转移
DOI：
10.1002/cac2.12294
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发表时间：
2022-05
期刊：
影响因子：
--
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Zhou H;Wang M;Zhang Y;Su Q;Xie Z;Chen X;Yan R;Li P;Li T;Qin X;Yang H;Wu C;You F;Li S;Liu Y
肿瘤细胞与周围微环境的动态、异质相互作用促进了实体瘤的发生、发展、侵袭和转移。在这个过程中，肿瘤微环境(TME)通过生化和机械手段破坏细胞和基质结构的正常，促进肿瘤的发生和治疗耐药。肿瘤细胞通过不同的机械转导途径感知和响应TME中机械信号的强度、方向和持续时间。然而，对机械转导的功能和机制的全面观点却知之甚少。由于TME的机械改变带来了巨大的治疗困难，新兴的研究集中在针对TME中的不利机械因素来减轻疾病，而不是传统的以肿瘤细胞本身为靶点，这已被证明是一种潜在的治疗方法。本文就机械因素在TME中的起源和作用、细胞感知、机械-生物耦合和信号转导、肿瘤力学微环境的体外构建、在TME中的应用和临床意义等方面进行了综述。
Dynamic and heterogeneous interaction between tumor cells and the surrounding microenvironment fuels the occurrence, progression, invasion, and metastasis of solid tumors. In this process, the tumor microenvironment (TME) fractures cellular and matrix architecture normality through biochemical and mechanical means, abetting tumorigenesis and treatment resistance. Tumor cells sense and respond to the strength, direction, and duration of mechanical cues in the TME by various mechanotransduction pathways. However, far less understood is the comprehensive perspective of the functions and mechanisms of mechanotransduction. Due to the great therapeutic difficulties brought by the mechanical changes in the TME, emerging studies have focused on targeting the adverse mechanical factors in the TME to attenuate disease rather than conventionally targeting tumor cells themselves, which has been proven to be a potential therapeutic approach. In this review, we discussed the origins and roles of mechanical factors in the TME, cell sensing, mechano‐biological coupling and signal transduction, in vitro construction of the tumor mechanical microenvironment, applications and clinical significance in the TME.
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影响因子：
64.5
作者：
Choquet, D;Felsenfeld, DP;Sheetz, MP
通讯作者：
Sheetz, MP
DOI：
10.1083/jcb.201701176
发表时间：
2017-11-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
Böttcher RT;Veelders M;Rombaut P;Faix J;Theodosiou M;Stradal TE;Rottner K;Zent R;Herzog F;Fässler R
通讯作者：
Fässler R
影响因子：
56.9
作者：
BELLA, J;EATON, M;BERMAN, HM
通讯作者：
BERMAN, HM
影响因子：
3.2
作者：
Acosta, Miguel A.;Jiang, Xiao;Gamcsik, Michael P.
通讯作者：
Gamcsik, Michael P.
影响因子：
2.4
作者：
Buwa, Natasha;Mazumdar, Debasmita;Balasubramanian, Nagaraj
通讯作者：
Balasubramanian, Nagaraj